INT30440

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Context Info
Confidence 0.29
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 2.39
Pain Relevance 15.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (Hps4) cytoplasmic membrane-bounded vesicle (Hps4) lysosome (Hps4)
cytoplasm (Hps4)
Anatomy Link Frequency
brain 2
striatum 1
neurites 1
central canal 1
horn 1
Hps4 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 136 100.00 Very High Very High Very High
mu opioid receptor 15 100.00 Very High Very High Very High
Dynorphin 66 99.92 Very High Very High Very High
substantia gelatinosa 10 99.68 Very High Very High Very High
Nucleus accumbens 9 99.24 Very High Very High Very High
opioid receptor 89 98.84 Very High Very High Very High
midbrain 2 98.38 Very High Very High Very High
Dorsal horn 10 98.36 Very High Very High Very High
opiate 9 96.84 Very High Very High Very High
Spinal cord 21 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 7 99.84 Very High Very High Very High
Targeted Disruption 6 94.24 High High
Immunization 8 92.60 High High
Increased Venous Pressure Under Development 2 90.28 High High
Hyperalgesia 6 85.44 High High
Pain 32 75.00 Quite High
INFLAMMATION 4 75.00 Quite High
Pressure And Volume Under Development 3 64.52 Quite High
Hypertrophy 1 48.72 Quite Low
Nociception 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No LE label was detected in the neuritic outgrowths from the cord-DRG explants, whereas high levels of opiate receptors develop in these outgrowths, primarily on the DRG neurites, by 1-2 weeks in culture.
Neg (No) Gene_expression (detected) of LE in neurites associated with opiate and enkephalin
1) Confidence 0.29 Published 1981 Journal Peptides Section Abstract Doc Link 7267405 Disease Relevance 0.18 Pain Relevance 0.73
Leu-enkephalin (LE) is also found in the SG, however, it is also present in quantity in the ventral horn and central canal areas.
Gene_expression (found) of LE in central canal associated with substantia gelatinosa and enkephalin
2) Confidence 0.13 Published 1981 Journal Peptides Section Abstract Doc Link 6167970 Disease Relevance 0 Pain Relevance 1.42
It was surprised to note that Bestatin, which controlled the ME level in the midbrain, had no effect on the concentration of this peptide in the striatum, nor on the LE concentration in both parts of the brain studied.
Gene_expression (concentration) of LE in brain associated with midbrain
3) Confidence 0.11 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.28 Pain Relevance 0.43
On the other hand, the different metabolisms between ME and LE in the brain were investigated (Belyaev et al., 1990).
Spec (investigated) Gene_expression (metabolisms) of LE in brain
4) Confidence 0.11 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.34 Pain Relevance 0.41
Leu-enkephalin (LE) is also found in the SG, however, it is also present in quantity in the ventral horn and central canal areas.
Gene_expression (found) of LE in horn associated with substantia gelatinosa and enkephalin
5) Confidence 0.04 Published 1981 Journal Peptides Section Abstract Doc Link 6167970 Disease Relevance 0 Pain Relevance 1.42
Boron-doped diamond thin film (BDD) electrodes have been used to study the oxidation reactions and to detect leucine-enkephalinamide (LEA) and its metabolites, tyrosine (T), tyrosyl-alanine (TA), tyrosyl-alanine-glycine (TAG) and leucine-enkephalin (LE) using cyclic voltammetry (CV), flow-injection analysis (FIA), and gradient liquid chromatography (LC) with amperometric detection.
Gene_expression (detect) of LE associated with enkephalin
6) Confidence 0.04 Published 2003 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Abstract Doc Link 12798166 Disease Relevance 0 Pain Relevance 0.28
These LE antibodies are highly specific of the C part of LE peptide and cross-react weakly with Met-enkephalin (1%).
Gene_expression (specific) of LE associated with enkephalin
7) Confidence 0.04 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3785585 Disease Relevance 0.32 Pain Relevance 0.99
Acute administration of 150 micrograms NE + 10 micrograms EE2 decreased the levels of methionine-enkephalin (ME), leucine-enkephalin (LE), dynorphin (DYN) and beta-endorphin like immunoreactivity (beta-EI) by about 50% in the pituitary.
Gene_expression (levels) of LE in pituitary associated with dynorphin and enkephalin
8) Confidence 0.04 Published 1985 Journal Peptides Section Abstract Doc Link 2866495 Disease Relevance 0 Pain Relevance 1.37
These LE antibodies are highly specific of the C part of LE peptide and cross-react weakly with Met-enkephalin (1%).
Gene_expression (specific) of LE associated with enkephalin
9) Confidence 0.03 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3785585 Disease Relevance 0.32 Pain Relevance 0.99
Leu5-enkephalin (LE), a potential endogenous ligand for MOR, is also present within neurons in this region.
Gene_expression (present) of LE in neurons associated with mu opioid receptor and enkephalin
10) Confidence 0.03 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8841907 Disease Relevance 0 Pain Relevance 0.94
Furthermore, levels of ir-met-enkephalin (ME) and ir-leu-enkephalin (LE) were unaffected.
Gene_expression (levels) of LE associated with enkephalin
11) Confidence 0.03 Published 1988 Journal Pain Section Abstract Doc Link 2906425 Disease Relevance 0.43 Pain Relevance 1.51
mu-Opioid receptors and their endogenous ligands, including Leu5-enkephalin (LE), are distributed abundantly in the nucleus accumbens (NAC), a region implicated in mechanisms of opiate reinforcement.
Gene_expression (distributed) of LE in nucleus accumbens associated with nucleus accumbens, opiate, enkephalin and opioid receptor
12) Confidence 0.03 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8753878 Disease Relevance 0 Pain Relevance 0.91
In the striatum, the levels of LE (33%) and DYN (115%) were elevated during chronic administration.
Gene_expression (levels) of LE in striatum associated with dynorphin and enkephalin
13) Confidence 0.02 Published 1985 Journal Peptides Section Abstract Doc Link 2866495 Disease Relevance 0 Pain Relevance 1.46
It is concluded that the acute administration of NE + EE2, in general, reduces the levels of ME, LE, DYN and beta-EI.
Gene_expression (levels) of LE associated with dynorphin and enkephalin
14) Confidence 0.02 Published 1985 Journal Peptides Section Abstract Doc Link 2866495 Disease Relevance 0 Pain Relevance 1.37
Ir-LE also showed large variations in different sites and no consistent relationships were found between the distribution of ir-Dyn-(1-8), Dyn-(1-13) and LE.
Gene_expression (distribution) of LE associated with enkephalin
15) Confidence 0.02 Published 1983 Journal Peptides Section Abstract Doc Link 6622288 Disease Relevance 0.53 Pain Relevance 0.75
Synthesis of Cellobiose-coupled LE (CcpLE)
Gene_expression (Synthesis) of LE associated with enkephalin
16) Confidence 0.02 Published 1998 Journal Biol Proced Online Section Body Doc Link PMC140124 Disease Relevance 0 Pain Relevance 0.34

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