INT304404

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.68
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (THRA) nucleoplasm (THRA) nucleus (THRA)
transcription factor binding (THRA)
Anatomy Link Frequency
blood 1
cerebral cortex 1
THRA (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 4 97.04 Very High Very High Very High
cytokine 16 76.88 Quite High
Inflammation 8 68.08 Quite High
depression 4 10.96 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 76 94.76 High High
INFLAMMATION 8 68.08 Quite High
Disease Progression 8 64.96 Quite High
Neurodegenerative Disease 12 63.84 Quite High
Autoimmune Disease 4 63.28 Quite High
Targeted Disruption 4 38.44 Quite Low
Schizophrenia 4 11.56 Low Low
Depression 4 10.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EAR normalization enables the validation of an appropriate control gene for any specific experimental design to be avoided.
Localization (normalization) of EAR
1) Confidence 0.12 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.06 Pain Relevance 0
EAR normalization applies to the quantification of mRNAs specifically expressed in blood
Localization (normalization) of EAR in blood
2) Confidence 0.11 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.25 Pain Relevance 0.17
These features make EAR amplification a reliable tool for normalization in RT-qPCR based on the principle that the differential expression of a small number of genes bearing the EAR will not influence EAR abundance in the transcriptome.
Localization (abundance) of EAR
3) Confidence 0.11 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0 Pain Relevance 0
These data demonstrate the efficiency of EAR normalization for quantifying a transcript of interest in other human tissues, such as cerebral cortex, that are normally subjected to a long post-mortem delay.
Localization (normalization) of EAR in cerebral cortex associated with cerebral cortex
4) Confidence 0.11 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.36 Pain Relevance 0.05

General Comments

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