INT30443

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Context Info
Confidence 0.54
First Reported 1985
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 30
Total Number 32
Disease Relevance 22.59
Pain Relevance 7.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 4
nodes 3
plasma 1
posterior 1
uterine 1
AIS (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 412 100.00 Very High Very High Very High
syringomyelia 66 100.00 Very High Very High Very High
Pain 37 100.00 Very High Very High Very High
Nav1.6 33 100.00 Very High Very High Very High
Nav1.2 540 99.98 Very High Very High Very High
potassium channel 45 99.98 Very High Very High Very High
Spinal cord 560 99.84 Very High Very High Very High
cva 174 99.70 Very High Very High Very High
analgesia 10 99.60 Very High Very High Very High
Multiple sclerosis 15 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Scoliosis 1931 100.00 Very High Very High Very High
Stroke 385 100.00 Very High Very High Very High
Breast Cancer 183 100.00 Very High Very High Very High
Intracranial Sinus Thrombosis 120 100.00 Very High Very High Very High
Syringomyelia 66 100.00 Very High Very High Very High
Reprotox - General 1 57 100.00 Very High Very High Very High
Pain 32 100.00 Very High Very High Very High
Reprotox - General 2 18 100.00 Very High Very High Very High
Thrombophilia 6 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

6 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Not only is linear vertebral column growth abnormally increased in AIS, but Dr Chu and colleagues report morphological evidence [2-4] of altered spinal cord shape about the curve apex suggesting that the cord is also affected ie a 'double pathology' may exist involving spine and cord (Figure 2).
Positive_regulation (increased) of AIS in spinal cord associated with scoliosis and spinal cord
1) Confidence 0.54 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.77 Pain Relevance 0.09
a) Vertebral growth (abnormally increased in AIS) may stretch a normal spinal cord without evident damage.
Positive_regulation (increased) of AIS in spinal cord associated with scoliosis and spinal cord
2) Confidence 0.54 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.71 Pain Relevance 0.24
Recent modeling data suggest that using AIs as upfront adjuvant treatment is better than using AIs in sequence after 2 or more years of tamoxifen (Cuzick et al 2003).
Positive_regulation (using) of AIs
3) Confidence 0.43 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.55 Pain Relevance 0
Overall, the available studies suggest that the differences in lipid profile between tamoxifen and AIs may be due to the lipid-lowering capacity of tamoxifen rather than to increases in lipid levels due to AIs.
Positive_regulation (increases) of AIs
4) Confidence 0.43 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.29 Pain Relevance 0
In addition, pathway connected to the non-acupuncture point is inhibited within the lateral periaqueductal gray when the analgesia inhibitory system (AIS) is activated.
Positive_regulation (activated) of AIS in lateral associated with acupuncture, central grey and analgesia
5) Confidence 0.40 Published 1985 Journal Acupunct Electrother Res Section Abstract Doc Link 2866673 Disease Relevance 0.10 Pain Relevance 0.91
The authors postulate that the increased prevalence of tonsillar ectopia, syringomyelia, abnormal SSEPs and abnormal postural balance in AIS are clinical manifestations of a common neuroanatomical abnormality all explained by a relatively shorter spinal cord in AIS.
Positive_regulation (increased) of AIS in spinal cord associated with scoliosis, syringomyelia and spinal cord
6) Confidence 0.39 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.91 Pain Relevance 0.30
In 2007, Moreau et al [111] reported the use of lymphocytes to develop a functional blood assay for the early detection of AIS and for the identification of children at risk of curve progression; this test can be performed without any prior knowledge of mutations in any defective genes causing AIS.
Positive_regulation (causing) of AIS in lymphocytes associated with scoliosis
7) Confidence 0.36 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.79 Pain Relevance 0.04
In a recent study [2,3], we found that the ratio of antero-posterior (AP) to transverse (TS) diameter of the cord was increased in AIS patients and correlated negatively with cord-to-vertebral length ratio (Moderator see [4]).
Positive_regulation (increased) of AIS in posterior associated with scoliosis
8) Confidence 0.36 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.64 Pain Relevance 0.18
Should thoracic AIS be caused by spinal cord tethering of the adjacent growing spine, how can cord tethering initiate thoracolumbar and lumbar AIS?
Positive_regulation (caused) of AIS in spinal cord associated with scoliosis and spinal cord
9) Confidence 0.36 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 1.34 Pain Relevance 0.26
The use of aromatase inhibitors (AIs) as adjuvant endocrine therapy for hormone-sensitive breast cancer is increasing, as these drugs are more effective than tamoxifen alone in improving disease-free survival in breast cancer patients-whether used in lieu of tamoxifen as upfront therapy or after tamoxifen treatment periods of 2 years or longer.
Spec (whether) Positive_regulation (increasing) of AIs associated with breast cancer and disease
10) Confidence 0.36 Published 2008 Journal Am. J. Clin. Oncol. Section Abstract Doc Link 19060594 Disease Relevance 0.56 Pain Relevance 0
Areas of increased signal (AIS) are detected on T2-weighted (T2W) pulse sequencies in 70-100% of patients with clinically definite MS.
Positive_regulation (increased) of AIS associated with multiple sclerosis
11) Confidence 0.32 Published 1997 Journal Srp Arh Celok Lek Section Abstract Doc Link 17974350 Disease Relevance 0.82 Pain Relevance 0.58
Adverse events associated with tamoxifen include increased risk of uterine cancers and thromboembolic events vs. an increased incidence of vaginal dryness, loss of libido, musculoskeletal pain and bone mineral density loss with AIs.
Positive_regulation (increased) of AIs in uterine associated with reprotox - general 2, pain, uterine cancer, cva and reprotox - general 1
12) Confidence 0.30 Published 2007 Journal International Journal of Clinical Practice Section Abstract Doc Link PMC2228389 Disease Relevance 0.80 Pain Relevance 0.15
These have produced possible linkages, three of which are designated IS1, IS2, and IS3 in Mendelian Inheritance in Man (MIM), an official registry of genetic disease loci.
Spec (possible) Positive_regulation (designated) of IS1 associated with disease
13) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674301 Disease Relevance 0.96 Pain Relevance 0.03
With the increased use of AIs as adjuvant hormonal therapy and the markedly greater suppression of plasma estrogens associated with such therapy, the effects of AI treatment on cognition will be important to consider.
Positive_regulation (increased) of AIs in plasma associated with cognitive disorder
14) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2747391 Disease Relevance 0.81 Pain Relevance 0.21
In the view of our findings, it is tempting to propose that CK2 regulates sodium channel interaction with ankyrin G and thus contributes to their specific accumulation at the AIS and the nodes of Ranvier.
Positive_regulation (accumulation) of AIS in nodes associated with sodium channel
15) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.38
A recent study found a marked increase in the use of AIs between the years 2000 and 2003, while the use of tamoxifen declined over the same time (Figure 1).1 In clinical trials, AIs have proven superior to tamoxifen in reducing breast cancer recurrence, although the treatment strategies examined have not been uniform across trials.
Positive_regulation (increase) of AIs in superior associated with breast cancer and recurrence
16) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2747391 Disease Relevance 0.37 Pain Relevance 0
Whereas the adverse event (AE) profile associated with AI treatment is largely predictable in women undergoing extreme estrogen deprivation, sporadic and/or unforeseen serious complications such as stroke, thromboembolism, and endometrial cancer can occur with tamoxifen.14,15 Although the findings of the major AI trials support the use of AIs in these different treatment settings, the weight of clinical evidence strongly supports the initial use of AIs, while a switch to an AI after tamoxifen is an option for patients who do not begin their adjuvant treatment with an AI.
Positive_regulation (support) of AIs associated with endometriosis (extended), stroke and cva
17) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2747391 Disease Relevance 0.29 Pain Relevance 0.05
As shown in Fig. 5, the photo-activated Kv2.1 within the AIS remained within the activation area and did not significantly re-distribute over the 42 min imaging period.
Positive_regulation (activated) of AIS associated with imagery
18) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2592246 Disease Relevance 0.06 Pain Relevance 0.17
Unlike the AIS, the formation of the nodes of Ranvier requires exquisite communication with myelinating cells.
Positive_regulation (requires) of AIS in nodes
19) Confidence 0.04 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0.18 Pain Relevance 0.12
We then calculated the total maximal conductance of the Nav1.6 channel over the AIS, by integrating the channel density over the surface of the AIS (using the morphology and channel density implemented in the published model code).
Positive_regulation (conductance) of AIS associated with nav1.6
20) Confidence 0.04 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900290 Disease Relevance 0 Pain Relevance 0.22

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