INT304434

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
C8-B4 2
macrophages 1
P2rx4 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 3 60.60 Quite High
gABA 3 59.80 Quite High
imagery 18 49.40 Quite Low
Neuropathic pain 27 15.12 Low Low
antidepressant 105 5.00 Very Low Very Low Very Low
Endep 48 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
Potency 12 5.00 Very Low Very Low Very Low
fluoxetine 9 5.00 Very Low Very Low Very Low
Desipramine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 33 15.12 Low Low
Targeted Disruption 3 9.36 Low Low
Myelodysplastic Syndromes 6 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The available data suggest that macrophages express P2X4 receptors in their resting state and decrease expression of this protein when they enter the activated state (Stokes and Surprenant, 2009).
Transcription (express) of P2X4 in macrophages
1) Confidence 0.60 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
We found significant amounts of P2X3, P2X4, P2X6, and P2X7 transcripts in resting C8-B4 cells with the following relative expression levels: P2X7 > P2X4 > P2X3 > P2X6.
Transcription (transcripts) of P2X4 in C8-B4
2) Confidence 0.60 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.06
However, of these, only P2X4 transcript levels were significantly increased by 2.4-fold in C8-B4 cells activated (Fig. 3) using conditions that give rise to ATP-evoked inward currents (Fig. 2).


Transcription (levels) of P2X4 in C8-B4
3) Confidence 0.46 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.05

General Comments

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