INT304444

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.75
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
microglia 4
C8-B4 2
P2rx4 (Mus musculus)
Pain Link Frequency Relevance Heat
Endep 96 99.84 Very High Very High Very High
allodynia 6 98.88 Very High Very High Very High
antidepressant 210 98.06 Very High Very High Very High
Eae 6 97.56 Very High Very High Very High
Neuropathic pain 54 92.20 High High
antagonist 36 91.76 High High
Dorsal horn 6 76.96 Quite High
Spinal cord 6 75.44 Quite High
imagery 36 23.40 Low Low
Potency 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 66 98.88 Very High Very High Very High
Myelodysplastic Syndromes 12 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Before proceeding further, we tested the effect of the Src family tyrosine kinase inhibitor PP2 (20 ยตM for 4 h with LPS) because previous work shows that this reduces P2X4 expression in microglia (Tsuda et al., 2008).
Negative_regulation (reduces) of Gene_expression (expression) of P2X4 in microglia
1) Confidence 0.51 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
Thus, strategies that reduce or abolish P2X4 expression alleviate symptoms such as allodynia that are a hallmark of neuropathic pain models (Tsuda et al., 2003; Ulmann et al., 2008).
Negative_regulation (abolish) of Gene_expression (expression) of P2X4 associated with allodynia and eae
2) Confidence 0.37 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.37 Pain Relevance 0.40
Thus, strategies that reduce or abolish P2X4 expression alleviate symptoms such as allodynia that are a hallmark of neuropathic pain models (Tsuda et al., 2003; Ulmann et al., 2008).
Negative_regulation (reduce) of Gene_expression (expression) of P2X4 associated with allodynia and eae
3) Confidence 0.37 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.37 Pain Relevance 0.40
It predicts that (a) amitriptyline should not affect total P2X4 proteins levels in activated C8-B4 cells (Fig. 14 A), (b) amitriptyline should reduce surface expression of P2X4 in activated C8-B4 cells (Fig. 14 B), (c) the effect of LPS to cause C8-B4 cells activation, and of MA to cause lysosomal secretion, would not be additive, as both strategies draw on the same lysosomal pool of P2X4 receptors (Fig. 14 C), and (d) the ability of MA to increase P2X4 responses would be reduced by amitriptyline if this drug affects lysosomes directly (Fig. 14 C).
Negative_regulation (reduce) of Gene_expression (expression) of P2X4 in C8-B4 associated with endep
4) Confidence 0.37 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.36
Surface biotinylation of P2X4 receptors
Negative_regulation (biotinylation) of Gene_expression (receptors) of P2X4
5) Confidence 0.37 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.04
However, we found that moderate concentrations of the same antidepressants reduced P2X4 responses in activated microglia by affecting lysosomal function, which indirectly reduced cell surface P2X4 levels.
Negative_regulation (reduced) of Gene_expression (levels) of P2X4 in microglia associated with antidepressant
6) Confidence 0.32 Published 2010 Journal The Journal of General Physiology Section Abstract Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.23

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