INT304463

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx4) mitochondrion (Ass1) endoplasmic reticulum (Ass1)
ligase activity (Ass1) cytoplasm (Ass1) signal transduction (P2rx4)
Anatomy Link Frequency
C8-B4 1
Ass1 (Mus musculus)
P2rx4 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 70 62.56 Quite High
Glutamate 2 54.44 Quite High
antagonist 12 53.84 Quite High
gABA 2 53.64 Quite High
imagery 12 43.24 Quite Low
Endep 32 5.00 Very Low Very Low Very Low
Neuropathic pain 18 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
fluoxetine 6 5.00 Very Low Very Low Very Low
Desipramine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 12.64 Low Low
Neuropathic Pain 22 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 4 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, of these, only P2X4 transcript levels were significantly increased by 2.4-fold in C8-B4 cells activated (Fig. 3) using conditions that give rise to ATP-evoked inward currents (Fig. 2).


2.4-fold Positive_regulation (increased) of P2X4 in C8-B4
1) Confidence 0.01 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.05
Using real-time polymerase chain reaction, we found that P2X4 transcripts were increased during the activated state by 2.4-fold, but this increase was not reflected by a parallel increase in total P2X4 proteins.
2.4-fold Positive_regulation (increased) of P2X4
2) Confidence 0.01 Published 2010 Journal The Journal of General Physiology Section Abstract Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.09

General Comments

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