INT304495

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.40
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Trib3, Mapk1) kinase activity (Trib3, Mapk1) nucleoplasm (Mapk1)
mitochondrion (Mapk1) Golgi apparatus (Mapk1) enzyme binding (Trib3)
Anatomy Link Frequency
brain stem 1
Trib3 (Rattus norvegicus)
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 110 98.40 Very High Very High Very High
medulla 22 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 124 97.48 Very High Very High Very High
Critical Illness 2 90.92 High High
Apoptosis 4 89.28 High High
Poisoning 14 65.04 Quite High
Toxicity 4 34.88 Quite Low
Pressure Volume 2 Under Development 8 25.00 Low Low
Overdose 2 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 2 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study assessed the hypothesis that extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinases (MAPKs) that is important for cell survival and is activated specifically by MAPK kinase 1/2 (MEK1/2), plays a pro-life role in RVLM during brain stem death.
kinase Positive_regulation (activated) of ERK1/2 in brain stem associated with rostral ventrolateral medulla and death
1) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2848001 Disease Relevance 0.60 Pain Relevance 0.24
As a member of the mitogen-activated protein kinases (MAPKs), ERK1/2 pathway is activated specifically by MAPK kinase 1/2 (MEK1/2), and is an important signal for cell survival [14-19].
kinase Positive_regulation (activated) of ERK1/2
2) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.80 Pain Relevance 0.10

General Comments

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