INT304504

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.93
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk1, Nos1) cytoplasm (Mapk1, Nos1) cytosol (Mapk1, Nos1)
nucleus (Mapk1, Nos1) cytoskeleton (Mapk1, Nos1) nucleoplasm (Mapk1)
Anatomy Link Frequency
brain stem 1
Mapk1 (Rattus norvegicus)
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 110 100.00 Very High Very High Very High
cerebral cortex 2 52.60 Quite High
Inflammatory response 2 45.52 Quite Low
medulla 22 14.16 Low Low
anesthesia 2 6.32 Low Low
Disease Link Frequency Relevance Heat
Death 124 100.00 Very High Very High Very High
Poisoning 14 98.58 Very High Very High Very High
Apoptosis 4 84.92 Quite High
Middle Cerebral Artery Infarction 2 49.72 Quite Low
INFLAMMATION 2 45.16 Quite Low
Toxicity 4 11.88 Low Low
Pressure Volume 2 Under Development 8 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Critical Illness 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on our Mev intoxication model [4], the present study evaluated the hypothesis that MEK1/2 and ERK1/2 in RVLM play a pro-life role during brain stem death by activating the NOS I/PKG cascade.
ERK1/2 Positive_regulation (activating) of NOS I in brain stem associated with rostral ventrolateral medulla, death and poisoning
1) Confidence 0.29 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.65 Pain Relevance 0.16
One possibility is for ERK1/2 to transcriptionally upregulate NOS I.
ERK1/2 Positive_regulation (upregulate) of NOS I
2) Confidence 0.19 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.27 Pain Relevance 0.14

General Comments

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