INT304528

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.76
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Map2k1) Golgi apparatus (Map2k1) cytoplasm (Map2k1)
cell proliferation (Map2k1) cytosol (Map2k1) mitosis (Map2k1)
Anatomy Link Frequency
cardiomyocyte 1
brain stem 1
reticulum 1
Map2k1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 110 99.36 Very High Very High Very High
medulla 22 56.08 Quite High
cva 2 49.16 Quite Low
ketamine 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 46 100.00 Very High Very High Very High
Poisoning 14 98.80 Very High Very High Very High
Death 138 97.60 Very High Very High Very High
Pressure Volume 2 Under Development 14 92.36 High High
Infection 22 91.84 High High
Apoptosis 8 85.36 High High
Bacillus Anthracis Infection 56 73.12 Quite High
Pressure And Volume Under Development 26 69.72 Quite High
Coronary Heart Disease 6 58.16 Quite High
Hemorrhage 2 49.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the stress signaling molecules MEK1/2, p38 MAP kinase, ERK and JNK as well as the essential Ca2+ regulatory proteins were also evaluated in an effort to better understand the mechanism of action behind lethal toxin-induced cardiomyocyte mechanical and intracellular Ca2+ handling responses, if any.


Gene_expression (Expression) of MEK1 in cardiomyocyte associated with stress
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.43 Pain Relevance 0
Expression of the stress signaling molecules MEK1/2, ERK, JNK and p38 MAP kinase, the intracellular Ca2+ regulatory proteins sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2a) and phospholamban, the ER stress proteins BIP (GRP78), pan and phospho-eIF2?
Gene_expression (Expression) of MEK1 in reticulum associated with stress
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.27 Pain Relevance 0
Activation of MEK1/2 or ERK1/2 underlies the augmentation of NOS I or PKG in RVLM during the pro-life phase
Gene_expression (/) of MEK1 associated with rostral ventrolateral medulla
3) Confidence 0.20 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.41 Pain Relevance 0.22
Based on our Mev intoxication model [4], the present study evaluated the hypothesis that MEK1/2 and ERK1/2 in RVLM play a pro-life role during brain stem death by activating the NOS I/PKG cascade.
Gene_expression (/) of MEK1 in brain stem associated with rostral ventrolateral medulla, death and poisoning
4) Confidence 0.20 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.65 Pain Relevance 0.15

General Comments

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