INT304570

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arntl) nucleus (Arntl) DNA binding (Arntl)
transcription factor binding (Arntl) cytoplasm (Arntl) signal transducer activity (Arntl)
Arntl (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 16 99.34 Very High Very High Very High
Dopamine 10 89.88 High High
Neurotransmitter 4 85.24 High High
depression 78 64.08 Quite High
Ventral tegmentum 4 54.72 Quite High
antidepressant 42 36.72 Quite Low
agonist 2 31.84 Quite Low
bDMF 26 5.00 Very Low Very Low Very Low
Hippocampus 21 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 86 64.08 Quite High
Manic Depressive Disorder 6 62.04 Quite High
Aging 27 52.72 Quite High
Targeted Disruption 4 44.72 Quite Low
Affective Disorder 20 43.44 Quite Low
Seasonal Affective Disorder 1 35.32 Quite Low
Neurodegenerative Disease 20 5.92 Low Low
Sleep Disorders 76 5.00 Very Low Very Low Very Low
Cognitive Disorder 24 5.00 Very Low Very Low Very Low
Stress 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, monoamine oxidase-A (MAO-A) expression is regulated by dimer formation of Clock and Bmal1, and MAO-A activity accordingly shows a circadian rhythmicity [118].
Regulation (regulated) of Bmal1 Binding (formation) of associated with monoamine
1) Confidence 0.26 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.30 Pain Relevance 0.43
Age alters the 24-h expression profile of CLOCK and its binding partner BMAL1 in the hamster SCN, but there is no effect of age on the 24-h profile of either Per1 or Per2 proteins when hamsters are housed in constant darkness.
Regulation (alters) of BMAL1 Binding (binding) of
2) Confidence 0.07 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.05 Pain Relevance 0

General Comments

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