INT304575

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.00
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
hippocampus 2
Creb1 (Mus musculus)
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 26 100.00 Very High Very High Very High
Hippocampus 15 98.52 Very High Very High Very High
antidepressant 42 97.52 Very High Very High Very High
depression 73 92.68 High High
Pyramidal cell 2 74.00 Quite High
fluoxetine 1 71.00 Quite High
carbamazepine 1 68.64 Quite High
sSRI 3 67.44 Quite High
imagery 5 25.68 Quite Low
withdrawal 8 20.16 Low Low
Disease Link Frequency Relevance Heat
Shock 3 96.96 Very High Very High Very High
Depression 81 92.68 High High
Neurodegenerative Disease 19 90.28 High High
Stress 17 55.80 Quite High
Affective Disorder 19 26.24 Quite Low
Substance Withdrawal Syndrome 1 7.20 Low Low
Manic Depressive Disorder 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study showed that CREB, a transcription factor that regulates expression of CRE-containing target genes including BDNF, is also upregulated and activated in hippocampus by chronic antidepressant treatment [2,53,68,69].
CREB Regulation (regulates) of Gene_expression (expression) of BDNF in hippocampus associated with antidepressant, hippocampus and bdmf
1) Confidence 0.04 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 1.00 Pain Relevance 0.84

General Comments

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