INT304576

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.43
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Arntl, Clock) cytoplasm (Arntl, Clock) signal transducer activity (Arntl, Clock)
signal transduction (Arntl, Clock) nucleus (Arntl, Clock) transcription factor binding (Arntl, Clock)
Arntl (Mus musculus)
Clock (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 16 98.96 Very High Very High Very High
Dopamine 9 89.12 High High
Neurotransmitter 3 84.48 Quite High
agonist 33 74.24 Quite High
depression 73 64.08 Quite High
Ventral tegmentum 4 53.96 Quite High
antidepressant 42 36.72 Quite Low
Angina 4 31.96 Quite Low
bDMF 26 5.00 Very Low Very Low Very Low
tetrodotoxin 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 15 69.52 Quite High
Depression 81 64.08 Quite High
Manic Depressive Disorder 6 61.28 Quite High
Affective Disorder 19 42.68 Quite Low
Seasonal Affective Disorder 1 34.56 Quite Low
Myocardial Infarction 4 33.04 Quite Low
Cv General 3 Under Development 4 31.96 Quite Low
Stroke 4 31.28 Quite Low
Cardiovascular Disease 4 30.68 Quite Low
Disease 32 28.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current simulation, we (1) explicitly modeled the binding of CLOCK:BMAL to regulatory regions of the Per1, Per2, Cry1, and Cry2 genes; (2) explicitly modeled the interaction of BMAL with CRY1 or CRY2 and its subsequent effects on transcriptional regulation; and (3) updated the rates of degradation of mRNAs and proteins using measurements from recent experiments [41].
BMAL Binding (interaction) of CLOCK
1) Confidence 0.37 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2953532 Disease Relevance 0 Pain Relevance 0
The acetylated Bmal1/CLOCK heterodimer then binds to the E-box (5?
Bmal1 Binding (heterodimer) of CLOCK
2) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.07 Pain Relevance 0
transcription by CLOCK/Bmal1 heterodimer upon binding to the E-box in the PPAR?
Bmal1 Binding (heterodimer) of CLOCK
3) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.04
transcription by CLOCK/Bmal1 heterodimer upon binding to the E-box in the PPAR?
Bmal1 Binding (heterodimer) of CLOCK
4) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.04
The acetylated Bmal1/CLOCK heterodimer then binds to the E-box (5?
Bmal1 Binding (heterodimer) of CLOCK
5) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.07 Pain Relevance 0
Moreover, monoamine oxidase-A (MAO-A) expression is regulated by dimer formation of Clock and Bmal1, and MAO-A activity accordingly shows a circadian rhythmicity [118].
Bmal1 Binding (formation) of Clock associated with monoamine
6) Confidence 0.16 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.29 Pain Relevance 0.43

General Comments

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