INT3046

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Context Info
Confidence 0.75
First Reported 1977
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 12.48
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (LGALS1) cytoplasm (LGALS1) signal transducer activity (LGALS1)
extracellular space (LGALS1) signal transduction (LGALS1) extracellular region (LGALS1)
Anatomy Link Frequency
CD86 2
macrophage 2
margin 2
internal 2
vasculature 1
LGALS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 17 100.00 Very High Very High Very High
Dismenorea 7 99.84 Very High Very High Very High
cytokine 79 93.72 High High
endometriosis 169 93.12 High High
Inflammation 102 92.32 High High
Angina 2 83.80 Quite High
Inflammatory response 3 83.20 Quite High
imagery 6 75.40 Quite High
Osteoarthritis 4 48.08 Quite Low
Potency 5 45.28 Quite Low
Disease Link Frequency Relevance Heat
Dermal Scarring 192 100.00 Very High Very High Very High
Dysmenorrhea 3 99.84 Very High Very High Very High
Skin Cancer 16 99.76 Very High Very High Very High
Lymphatic System Cancer 368 99.68 Very High Very High Very High
Hodgkin's Disease 75 99.66 Very High Very High Very High
Endometriosis 224 99.44 Very High Very High Very High
B-cell Lymphoma 81 99.44 Very High Very High Very High
Colitis 17 99.36 Very High Very High Very High
Mesothelioma 2 98.68 Very High Very High Very High
Infection 53 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mature DCs express high levels of Class I and Class II molecules, altered chemokine and galectin family (Dietz et al 2000; Bax et al 2007) expression, co-stimulatory markers CD80 and CD86, and the immunoglobulin CD83 (Zhou and Tedder 1995).
Gene_expression (express) of galectin in CD86 associated with chemokine
1) Confidence 0.75 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.38 Pain Relevance 0.10
Frequent expression of accessible ligands for endogenous lectins galectins-1 and -3, the expression of the angiogenic macrophage migration inhibitory factor (MIF), and the dense vascularization intimate a functional relationship.
Gene_expression (expression) of galectin in macrophage
2) Confidence 0.75 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 16308104 Disease Relevance 1.25 Pain Relevance 0.12
Mature DCs express high levels of Class I and Class II molecules, altered chemokine and galectin family (Dietz et al 2000; Bax et al 2007) expression, co-stimulatory markers CD80 and CD86, and the immunoglobulin CD83 (Zhou and Tedder 1995).
Gene_expression (expression) of galectin in CD86 associated with chemokine
3) Confidence 0.58 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.39 Pain Relevance 0.10
-Galactosidase, which is constitutively expressed in the Rosa26-derived CPCs (Figs. 3i, l). ?
Gene_expression (expressed) of Gal
4) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.66 Pain Relevance 0
Frequent expression of accessible ligands for endogenous lectins galectins-1 and -3, the expression of the angiogenic macrophage migration inhibitory factor (MIF), and the dense vascularization intimate a functional relationship.
Gene_expression (expression) of galectin in macrophage
5) Confidence 0.58 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 16308104 Disease Relevance 1.22 Pain Relevance 0.12
Immunoreactive alpha-melanotropin was spontaneously released from a melanoma cell line (HBL) expressing melanotropin receptors on the cell surface.
Gene_expression (expressing) of HBL associated with skin cancer
6) Confidence 0.58 Published 1997 Journal Eur. J. Biochem. Section Abstract Doc Link 9108267 Disease Relevance 0.83 Pain Relevance 0
To study the role of PRL in the regulation of the production of 17 beta-estradiol, progesterone, testosterone, and human placental lactogen (hPL), 11 healthy women were given 150 mg sulpiride daily for 14 days, beginning between weeks 6--9 of normal gestation.
Gene_expression (production) of hPL
7) Confidence 0.48 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7380989 Disease Relevance 0 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of LGALS1 in internal associated with dermal scarring
8) Confidence 0.46 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
Serum PAPP-A, progesterone, LIF, HPL, and glycodelin levels did not significantly differ between the two groups.
Gene_expression (levels) of HPL
9) Confidence 0.38 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.38 Pain Relevance 0.03
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of LGALS1 in internal associated with dermal scarring
10) Confidence 0.20 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of LGALS1 in margin associated with dermal scarring
11) Confidence 0.16 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
Rodig et al. studied the expression of GAL1 and AP1 pathway proteins in 225 cases of various lymphomas and found that Gal1 is selectively expressed by Reed–Sternberg cells in >90% of primary cHLs and ALCL, in concordance with the activated AP1 component, c-jun.
Gene_expression (expressed) of Gal1 associated with lymphatic system cancer
12) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.17 Pain Relevance 0
Rodig et al. studied the expression of GAL1 and AP1 pathway proteins in 225 cases of various lymphomas and found that Gal1 is selectively expressed by Reed–Sternberg cells in >90% of primary cHLs and ALCL, in concordance with the activated AP1 component, c-jun.
Gene_expression (expression) of GAL1 associated with lymphatic system cancer
13) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.17 Pain Relevance 0
In contrast, DLBCL, primary mediastinal large B cell lymphoma, and another Hodgkin-related entity, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), do not express Gal1 [3].


Neg (not) Gene_expression (express) of Gal1 in lymphocyte associated with b-cell lymphoma, hodgkin's disease and diffuse large b-cell lymphoma
14) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.10 Pain Relevance 0
However, Gal-1 is constitutively expressed in most organs [5], showing that Gal-1 broadly, but also nonspecifically, interact with the immune system.
Gene_expression (expressed) of Gal-1 in immune system
15) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.55 Pain Relevance 0.32
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of LGALS1 in margin associated with dermal scarring
16) Confidence 0.07 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
However, to date, no data are available indicating the regulated expression of Gal-1 and Gal-3 in endometriotic tissue.
Gene_expression (expression) of Gal-1 associated with endometriosis
17) Confidence 0.05 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.73 Pain Relevance 0.17
The expression of galectin 1 and galectin 3 were up-regulated in Trichinella infection.
Gene_expression (expression) of galectin 1 associated with infection
18) Confidence 0.01 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.10 Pain Relevance 0
Focal immunoreactivity for CD31, factor VIII-related antigen, and lectin UEA-1 was present in the endothelial cells lining the vasculature.
Gene_expression (present) of lectin UEA-1 in vasculature
19) Confidence 0.01 Published 2008 Journal J Orthop Sci Section Body Doc Link PMC2778709 Disease Relevance 0.25 Pain Relevance 0.05
Vital signs, intrauterine pressure, serum levels of steroid hormones, hPL and hCG were recorded before, during and after administration of Pg SH B 286.
Gene_expression (levels) of hPL associated with dismenorea
20) Confidence 0.00 Published 1977 Journal Geburtshilfe Frauenheilkd Section Abstract Doc Link 604150 Disease Relevance 0.50 Pain Relevance 0.10

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