INT304603

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 7.01
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1)
response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)
HSP90AA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 4 82.24 Quite High
Inflammation 4 72.72 Quite High
Hippocampus 4 62.20 Quite High
Angina 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 28 100.00 Very High Very High Very High
Shock 8 100.00 Very High Very High Very High
Disease 380 99.64 Very High Very High Very High
Hypoxia 4 98.40 Very High Very High Very High
Targeted Disruption 8 89.04 High High
Alzheimer's Dementia 12 76.80 Quite High
INFLAMMATION 4 72.72 Quite High
Dementia 24 68.96 Quite High
Aging 16 52.72 Quite High
Cardiovascular Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypoxia, known to cause oxidative stress, was elevated in clinical AD [31], causing an increase in stress response proteins such as heat shock 90 kDa protein 1 alpha (HSP90) [32,33].
Positive_regulation (increase) of HSP90 associated with stress, hypoxia, shock and disease
1) Confidence 0.26 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2848146 Disease Relevance 1.89 Pain Relevance 0.06
Hypoxia, known to cause oxidative stress, was elevated in clinical AD [31], causing an increase in stress response proteins such as heat shock 90 kDa protein 1 alpha (HSP90) [32,33].
Positive_regulation (increase) of heat shock 90 kDa protein 1 alpha associated with stress, hypoxia, shock and disease
2) Confidence 0.26 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2848146 Disease Relevance 1.89 Pain Relevance 0.06
For HSP90 we confirmed our MS data (Table 2) using western blot analysis of RBC membrane proteins with a monoclonal HSP90 antibody, showing an elevation of HSP90 in four out of five AD subjects (Figure 3).
Positive_regulation (elevation) of HSP90 associated with disease
3) Confidence 0.26 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2848146 Disease Relevance 1.79 Pain Relevance 0.08
We validated the increase of HSP90 in the RBC membrane proteome from AD subjects by using western blot analysis (Figure 3A &3B).
Positive_regulation (increase) of HSP90 associated with disease
4) Confidence 0.26 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2848146 Disease Relevance 1.44 Pain Relevance 0.03

General Comments

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