INT304623

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0.53

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)

Anatomy Link Frequency neurons 2 Tbpl1 (Mus musculus)

Pain Link Frequency Relevance Heat TRP channel 5 100.00 dorsal root ganglion 24 98.68 trigeminal ganglion 22 79.76 Neuronal excitability 1 67.64 Pain 38 60.16 Hyperalgesia 15 50.00 allodynia 9 28.32 Cold hyperalgesia 7 23.20 Peripheral nervous system 2 8.60 withdrawal 13 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 46 98.68 Drug Induced Neurotoxicity 3 76.96 Pain 26 60.16 Hyperalgesia 34 50.00 Body Weight 9 37.20 Neuropathic Pain 28 28.32 INFLAMMATION 10 5.00 Non-diabetic Peripheral Neuropathy 10 5.00 Hypersensitivity 9 5.00 Nociception 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These observations reveal distinct underlying mechanisms of TRP channel transcriptional regulation by cisplatin and oxaliplatin in DRG neurons.

Regulation (underlying) of Regulation (regulation) of TRP in neurons associated with dorsal root ganglion and trp channel

1) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.76 Pain Relevance 0.53

General Comments

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