INT304624

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.64
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 4
nociceptors 2
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 40 99.68 Very High Very High Very High
dorsal root ganglion 96 99.16 Very High Very High Very High
Thermal hyperalgesia 44 97.16 Very High Very High Very High
TRP channel 20 96.64 Very High Very High Very High
allodynia 36 95.72 Very High Very High Very High
trigeminal ganglion 88 88.00 High High
Hyperalgesia 60 80.96 Quite High
Pain 152 75.08 Quite High
Peripheral nervous system 8 70.96 Quite High
Neuronal excitability 4 62.84 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 184 99.16 Very High Very High Very High
Hyperalgesia 136 97.16 Very High Very High Very High
Neuropathic Pain 112 95.72 Very High Very High Very High
Nervous System Injury 32 78.24 Quite High
Non-diabetic Peripheral Neuropathy 40 75.52 Quite High
Drug Induced Neurotoxicity 12 72.16 Quite High
Pain 104 68.40 Quite High
Death 12 51.04 Quite High
Hypersensitivity 36 47.72 Quite Low
Body Weight 36 45.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cisplatin induced up-regulations of TRPV1 and TRPA1 mRNA in vivo
Positive_regulation (induced) of Regulation (regulations) of TRPA1 mRNA
1) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.78 Pain Relevance 0.55
Cisplatin induced significant up-regulation of TRPV1 and TRPA1 mRNA (3-fold) in cultured DRG neurons at 6 h (Figure 2A and 2C).
Positive_regulation (up) of Regulation (regulation) of TRPA1 mRNA in neurons associated with dorsal root ganglion
2) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.47 Pain Relevance 0.27
We also illustrate that up-regulation of TRPV1 and TRPA1 mRNA reflects increases in TRPV1 and TRPA1 responsiveness in the nociceptors that contribute to the molecular mechanisms of the thermal hyperalgesia and mechanical allodynia observed in cisplatin-treated mice.
Positive_regulation (increases) of Regulation (responsiveness) of TRPA1 in nociceptors associated with allodynia, thermal hyperalgesia and nociceptor
3) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.92 Pain Relevance 0.67
Cisplatin induced significant up-regulation of TRPV1 and TRPA1 mRNA (3-fold) in cultured DRG neurons at 6 h (Figure 2A and 2C).
Positive_regulation (induced) of Regulation (regulation) of TRPA1 mRNA in neurons associated with dorsal root ganglion
4) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.47 Pain Relevance 0.27

General Comments

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