INT304633

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.19
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
blood vessels 2
vessels 2
bile 2
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 64 99.86 Very High Very High Very High
ischemia 11 98.00 Very High Very High Very High
Inflammation 9 33.44 Quite Low
cytokine 2 32.40 Quite Low
Central nervous system 8 5.84 Low Low
tolerance 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Cholecystokinin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Hemorrhage 4 98.60 Very High Very High Very High
Obesity 32 50.00 Quite Low
INFLAMMATION 9 33.44 Quite Low
Sprains And Strains 17 5.00 Very Low Very Low Very Low
Body Weight 11 5.00 Very Low Very Low Very Low
Diabetes Mellitus 10 5.00 Very Low Very Low Very Low
Metabolic Disorder 9 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 8 5.00 Very Low Very Low Very Low
Hypoxia 6 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meanwhile, Raimondi et al. [23] reported that unconjugated bile acids increased TJ permeability via occludin dephosphorylation, but not via any reduction in TJ protein expression, in Caco-2 cells.
Neg (not) Positive_regulation (increased) of Phosphorylation (dephosphorylation) of occludin in bile associated with bile
1) Confidence 0.28 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0 Pain Relevance 0.37
Increased phosphorylation of occludin at tyrosine residue is shown in a focal cerebral ischemia model of the BBB disruption, further supporting a role for tight junction protein phosphorylation in regulating the permeability of blood vessels [38].
Positive_regulation (Increased) of Phosphorylation (phosphorylation) of occludin in blood vessels associated with brain hemorrhage and ischemia
2) Confidence 0.22 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.10 Pain Relevance 0.05
In fact, elevated ser/thre phosphorylation of occludin promotes the assembly of the tight junctions, resulting in a reduction in permeable vessels [39].
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of occludin in vessels
3) Confidence 0.22 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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