INT304694

Context Info Confidence 0.15 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 3.71 Pain Relevance 0.16

Anatomy Link Frequency macrophage 1 lungs 1 Lvs (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 81 97.36 Inflammation 18 5.00 Inflammatory response 14 5.00 anesthesia 5 5.00 ketamine 2 5.00 chemokine 2 5.00 Tendonitis 2 5.00 Inflammatory mediators 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Sprains And Strains 413 100.00 Infection 327 100.00 Disease 55 96.80 Francisella Infection 121 89.24 Targeted Disruption 14 54.08 Insect Bites And Stings 2 37.28 Injury 4 36.72 Death 40 5.00 INFLAMMATION 33 5.00 Convalescence 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Production of IL-17A in the lungs following intranasal infection with LVS

LVS Binding (infection) of in lungs associated with sprains and strains and infection

1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.30 Pain Relevance 0.16

following intransal infection with LVS.

LVS Binding (infection) of associated with sprains and strains and infection

2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.57 Pain Relevance 0

Unlike mice, Fischer rats exhibited a high degree of resistance to pulmonary challenge with LVS (an attenuated derivative of subsp. holarctica) and subsp. novicida.

LVS Binding (exhibited) of

3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2848594 Disease Relevance 0.35 Pain Relevance 0

g/ml); and for F. tularensis LVS the MIC was 0.39 ?

LVS Binding (0.39) of associated with sprains and strains

4) Confidence 0.02 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2881020 Disease Relevance 0.92 Pain Relevance 0

J774A.1 mouse macrophage were infected with F. philomiragia, F. novicida, and F. tularensis LVS and treated with Az.

LVS Binding (infected) of in macrophage associated with sprains and strains

5) Confidence 0.02 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2881020 Disease Relevance 0.57 Pain Relevance 0

General Comments

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