INT304810

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
quadriceps 2
RT1-CE1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 112 99.08 Very High Very High Very High
agonist 20 75.00 Quite High
Pain 20 72.16 Quite High
antagonist 4 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 110 99.08 Very High Very High Very High
Hypertrophy 24 95.52 Very High Very High Very High
Disease 6 80.08 Quite High
Pain 16 72.16 Quite High
Weight Gain 8 17.72 Low Low
Frailty 8 5.00 Very Low Very Low Very Low
Muscle Weakness 6 5.00 Very Low Very Low Very Low
Fatigue 4 5.00 Very Low Very Low Very Low
Atrophic Muscular Disorders 4 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of interest we found that although no changes to the MHC protein composition were noted in response to clenbuterol prior to surgery, subtle effects of clenbuterol on MHC protein expression were observed in the period post surgery where clenbuterol suppressed the trend towards an MNX surgery-induced increase in MHC I.
Regulation (effects) of Gene_expression (expression) of MHC protein
1) Confidence 0.11 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.38 Pain Relevance 0.20
Meniscal surgery resulted in the development of OA-like lesions, changes to weight bearing, and changes in MHC protein expression in the quadriceps.
Spec (like) Regulation (changes) of Gene_expression (expression) of MHC protein in quadriceps associated with osteoarthritis
2) Confidence 0.07 Published 2010 Journal Osteoarthritis and Cartilage Section Abstract Doc Link PMC2849930 Disease Relevance 0.89 Pain Relevance 0.28

General Comments

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