INT304811

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.29 Pain Relevance 0.10

RT1-CE1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 10 87.36 Pain 10 54.40 Osteoarthritis 56 43.60 antagonist 2 5.00 analgesia 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Weight Gain 4 91.36 Disease 3 74.68 Hypertrophy 12 72.84 Pain 8 54.40 Osteoarthritis 55 43.60 Frailty 4 5.00 Muscle Weakness 3 5.00 Fatigue 2 5.00 Atrophic Muscular Disorders 2 5.00 Disease Progression 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Electrophoretic analysis of MHC isoforms demonstrated that clenbuterol pre-treatment prior to MNX suppressed the increase in MHC I protein, which was previously associated with MNX surgery, and numerically, maintained the MHC IIB complement (Table II).

Negative_regulation (suppressed) of Positive_regulation (increase) of MHC I protein

1) Confidence 0.11 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.29 Pain Relevance 0.10

General Comments

This test has worked.