INT304823

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.39
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rasa1) cell adhesion (Rasa1) plasma membrane (Rasa1)
intracellular (Rasa1) embryo development (Rasa1) cytoplasm (Rasa1)
Anatomy Link Frequency
cardiac muscle 2
muscle 1
skeletal muscle 1
Rasa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 45 99.68 Very High Very High Very High
sodium channel 5 97.88 Very High Very High Very High
tetrodotoxin 25 95.52 Very High Very High Very High
imagery 15 63.28 Quite High
Action potential 5 51.48 Quite High
medulla 13 5.00 Very Low Very Low Very Low
Calcium channel 5 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Contracture 5 94.92 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 82.48 Quite High
Deafness 15 76.88 Quite High
Tinnitus 96 71.16 Quite High
Anxiety Disorder 9 5.00 Very Low Very Low Very Low
Hyperacusis 3 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Halothane was used as an inhibitor of gap junctions [27].
Negative_regulation (inhibitor) of gap associated with halothane
1) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2850148 Disease Relevance 0.09 Pain Relevance 0.46
An inhibitor of gap junctions, halothane, failed to affect EFS-induced contractile responses in esophageal muscle, whereas the inhibitor blocked those in cardiac muscle.
Negative_regulation (inhibitor) of gap in cardiac muscle associated with halothane
2) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2850148 Disease Relevance 0 Pain Relevance 0.10
Effects of an Inhibitor of Gap Junctions on EFS-Induced Contractions in Esophageal and Cardiac Muscles
 To clarify the involvement of gap junctions in the contractile responses, we examined the effects of an inhibitor of gap junctions, halothane, on the EFS-induced contractions in esophageal and cardiac muscles.  
Negative_regulation (inhibitor) of gap in cardiac muscles associated with halothane
3) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2850148 Disease Relevance 0 Pain Relevance 0.14
The contractions of esophageal muscle were not affected by an inhibitor of gap junctions.
Negative_regulation (inhibitor) of gap in muscle
4) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2850148 Disease Relevance 0 Pain Relevance 0
The major findings are (1) EFS with single pulses evoked twitch-like contractile responses in esophageal muscle, similar to those in skeletal muscle in duration and similar to those in cardiac muscle in amplitude, (2) EFS with a high frequency induced a transient summation of contractions followed by a sustained contraction with an amplitude comparable to that of twitch-like contraction induced by the single-pulse EFS, (3) an inhibitor of gap junctions did not affect the esophageal contractions, and (4) both high potassium stimulation and application of caffeine induced contractions of esophageal muscle in a manner analogous to that of skeletal muscle.
Negative_regulation (inhibitor) of gap in skeletal muscle
5) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2850148 Disease Relevance 0 Pain Relevance 0
For each animal both pre-pulse inhibition (pASR) and gap detection inhibition (gASR) of acoustic startle was conducted.
Negative_regulation (inhibition) of gap
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.30 Pain Relevance 0.06

General Comments

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