INT304863

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.91
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nanog) nucleoplasm (Nanog) nucleolus (Nanog)
nucleus (Nanog) embryo development (Nanog) DNA binding (Nanog)
Nanog (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 24 96.36 Very High Very High Very High
Glutamate receptor 6 91.60 High High
Glutamate 72 88.68 High High
nMDA receptor 36 86.32 High High
Action potential 30 85.12 High High
depression 6 63.52 Quite High
GABAergic 6 57.36 Quite High
cerebral cortex 9 47.44 Quite Low
Thalamus 6 17.92 Low Low
Neurotransmitter 6 15.44 Low Low
Disease Link Frequency Relevance Heat
Cancer 6 96.32 Very High Very High Very High
Teratoma 12 92.48 High High
Apoptosis 6 74.16 Quite High
Depression 6 63.52 Quite High
Disease 57 50.00 Quite Low
Drug Induced Neurotoxicity 6 45.00 Quite Low
Shock 3 39.24 Quite Low
Stress 6 34.08 Quite Low
Injury 42 32.08 Quite Low
Myocardial Infarction 39 31.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased enk expression is one of the earliest molecular markers of neuropathology in HD mice (Menalled et al., 2000).
Negative_regulation (Decreased) of Gene_expression (expression) of enk
1) Confidence 0.41 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.06 Pain Relevance 0.08
Enk expression is tightly regulated by cortical inputs (Uhl et al., 1988) and decreased cortical communication will reduce enk expression in these MSSNs.
Negative_regulation (decreased) of Gene_expression (expression) of Enk
2) Confidence 0.41 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.07 Pain Relevance 0.39
No colonies of undifferentiated ESCs were detected as confirmed by the absence of Pou5f1 and Nanog expression.


Negative_regulation (absence) of Gene_expression (expression) of Nanog
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0 Pain Relevance 0.04
We have previously demonstrated that no expression of Nanog or Pou5f1 was detected following Nkx2-5(+) CPC derivation and extended culture in vitro.
Negative_regulation (detected) of Neg (no) Gene_expression (expression) of Nanog
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.37 Pain Relevance 0
In contrast, colonies of undifferentiated ESCs and high expression levels of Nanog and Pou5f1 were found in cultures of the sorted GFP(?)
Negative_regulation (levels) of Gene_expression (expression) of Nanog
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.34 Pain Relevance 0
Enk expression is tightly regulated by cortical inputs (Uhl et al., 1988) and decreased cortical communication will reduce enk expression in these MSSNs.
Negative_regulation (reduce) of Gene_expression (expression) of enk
6) Confidence 0.30 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.07 Pain Relevance 0.33

General Comments

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