INT304882

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2, Mapk1) transcription factor binding (Agtr2, Mapk1) nucleoplasm (Mapk1)
mitochondrion (Mapk1) protein complex (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
fibroblasts 1
Agtr2 (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 68.32 Quite High
tetrodotoxin 2 60.04 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 2 98.56 Very High Very High Very High
Diabetes Mellitus 254 97.20 Very High Very High Very High
Stress 38 74.64 Quite High
Neurodegenerative Disease 16 50.00 Quite Low
Body Weight 12 42.52 Quite Low
Apoptosis 16 30.28 Quite Low
Diabetic Retinopathy 16 5.00 Very Low Very Low Very Low
Age-related Macular Degeneration 10 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase is cancelled by the NADH/NADPH oxidase inhibitor that reduces intracellular ROS, indicating that angiotensin II stimulates ROS production via AT1R and NADH/NADPH oxidase, to activate ERK [36].
angiotensin II Positive_regulation (activate) of ERK
1) Confidence 0.07 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.50 Pain Relevance 0.11
In cardiac fibroblasts, angiotensin II increases the intracellular ROS and ERK activation through AT1R, to induce cardiac hypertrophy.
angiotensin II Positive_regulation (increases) of ERK in fibroblasts associated with coronary heart disease
2) Confidence 0.03 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.45 Pain Relevance 0.09

General Comments

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