INT304986

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.87
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VTA1) endosome (VTA1) cytoplasm (VTA1)
VTA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Ventral tegmentum 17 100.00 Very High Very High Very High
addiction 52 97.96 Very High Very High Very High
Dopamine 28 97.92 Very High Very High Very High
Nucleus accumbens 10 96.00 Very High Very High Very High
Locus ceruleus 13 95.52 Very High Very High Very High
antagonist 1 91.48 High High
excitatory amino acid 1 91.00 High High
Glutamate 5 88.88 High High
withdrawal 20 79.52 Quite High
Opioid 71 79.08 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 43 100.00 Very High Very High Very High
Recurrence 11 98.44 Very High Very High Very High
Depression 116 97.44 Very High Very High Very High
Anxiety Disorder 18 87.40 High High
Opiate Addiction 29 84.00 Quite High
Substance Withdrawal Syndrome 8 79.88 Quite High
Cognitive Disorder 4 68.56 Quite High
Drug Dependence 11 64.00 Quite High
Pain 3 43.04 Quite Low
Stress 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FA abnormalities in the VTA/SN region
Regulation (abnormalities) of Gene_expression (region) of VTA/SN associated with congenital anomalies
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993928 Disease Relevance 1.22 Pain Relevance 0
The excitatory cortical pathways may produce little response in the VTA during the resting state, leading to reductions in DA.
Neg (little) Spec (may) Regulation (response) of Neg (little) Gene_expression (produce) of VTA associated with ventral tegmentum and dopamine
2) Confidence 0.30 Published 2002 Journal Sci Pract Perspect Section Body Doc Link PMC2851054 Disease Relevance 0.65 Pain Relevance 1.24

General Comments

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