INT305001

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.22
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ACAN, TNFAIP6) signal transduction (TNFAIP6) extracellular region (ACAN)
proteinaceous extracellular matrix (ACAN) cell-cell signaling (TNFAIP6)
Anatomy Link Frequency
proximal 1
ACAN (Homo sapiens)
TNFAIP6 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 3 99.70 Very High Very High Very High
Inflammation 2 94.44 High High
metalloproteinase 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Internal Fibrosis 2 99.70 Very High Very High Very High
Dermal Scarring 48 97.40 Very High Very High Very High
INFLAMMATION 2 94.44 High High
Disease 25 94.28 High High
Keloid Scars 6 75.76 Quite High
Chromosome Aberrations 1 70.16 Quite High
Apoptosis 3 58.84 Quite High
Cancer 6 55.96 Quite High
Bladder Cancer 1 23.84 Low Low
Thyroid Neoplasm 3 11.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNFAIP6 was shown to be involved in the inhibition of neutrophil migration, modulation of inflammation, and tissue remodeling.38 In individuals with renal fibrosis, increased expression of TNFAIP6 was reported in the proximal tubular epithelial cells, a cell population that was demonstrated to have the potential to contribute to the pathogenesis of renal fibrosis.39 Similar to ACAN, TNFAIP6 also interacts with hyaluronic acid, which has been shown to be upregulated in keloid fibroblasts.27 Although Marneros et al20 did not identify mutations or disease-associated polymorphisms in the TNFAIP6 gene when screening genomic DNA of the affected and unaffected family members of the Japanese family used to establish the 2q23 keloid linkage.
ACAN Binding (interacts) of TNFAIP6 in proximal associated with fibrosis, dermal scarring, inflammation, disease and internal fibrosis
1) Confidence 0.28 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.22 Pain Relevance 0.14

General Comments

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