INT305019

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 5.10
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NREP) cytoplasm (NREP)
Anatomy Link Frequency
smooth muscle 6
margin 2
fibroblast 2
NREP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 2 83.48 Quite High
Inflammation 10 77.84 Quite High
cytokine 8 63.76 Quite High
metalloproteinase 6 61.92 Quite High
Pain 8 5.00 Very Low Very Low Very Low
pruritus 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
dysesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cicatrix 84 99.84 Very High Very High Very High
Keloid Scars 342 99.28 Very High Very High Very High
Dermal Scarring 96 99.04 Very High Very High Very High
Burns 24 96.20 Very High Very High Very High
Injury 48 94.48 High High
Disease 56 83.92 Quite High
Osteoarthritis 2 83.48 Quite High
INFLAMMATION 10 77.84 Quite High
Wound Healing 24 76.36 Quite High
Hypertrophy 12 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of C5ORF13 has been shown to induce nonfibrogenic myofibroblast-like phenotype in 3T3 cells, including upregulation of smooth muscle ?
Positive_regulation (induce) of Gene_expression (expression) of C5ORF13 in smooth muscle
1) Confidence 0.44 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.71 Pain Relevance 0.13
1.30 The expression of C5ORF13 is shown to be upregulated by approximately 10-fold in keloid margin (P = .000).
Positive_regulation (upregulated) of Gene_expression (expression) of C5ORF13 in margin associated with dermal scarring
2) Confidence 0.44 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.69 Pain Relevance 0.12
Moreover, the proportion of cells in S phase was increased from 0.3% to 6.0% following P311 expression (Fig. 2C and 2D).
Positive_regulation (increased) of Gene_expression (expression) of P311
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.32 Pain Relevance 0
Transfection of fibroblasts with P311 gene stimulated the expression of alpha-smooth muscle actin (?
Positive_regulation (stimulated) of Gene_expression (Transfection) of P311 in smooth muscle
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852399 Disease Relevance 0.59 Pain Relevance 0
Transfection of fibroblasts with P311 gene stimulated the expression of alpha-smooth muscle actin (?
Positive_regulation (Transfection) of Gene_expression (Transfection) of P311 in smooth muscle
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852399 Disease Relevance 0.58 Pain Relevance 0
However our current work also indicated that the forced expression of P311 was associated with increased levels of TGF-?
Positive_regulation (forced) of Gene_expression (expression) of P311
6) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.30 Pain Relevance 0
Among these P311 gene expression increased conspicuously in hypertrophic scar tissue [3].
Positive_regulation (increased) of Gene_expression (expression) of P311 associated with keloid scars
7) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 1.11 Pain Relevance 0.07
Furthermore as P311 expression was elevated in scar tissues, we tested the effects of inhibition of P311 expression on the properties of scar-derived fibroblast-like cells.
Positive_regulation (elevated) of Gene_expression (expression) of P311 in fibroblast associated with cicatrix
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.80 Pain Relevance 0

General Comments

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