INT305029

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Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 5.94
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Adcy1) plasma membrane (Adcy1) nucleus (Adcy1)
Anatomy Link Frequency
forebrain 1
amygdala 1
cortex 1
synapse 1
hippocampus 1
Adcy1 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 144 99.72 Very High Very High Very High
Anterior cingulate cortex 18 99.52 Very High Very High Very High
Hippocampus 162 98.72 Very High Very High Very High
Pain 31 97.52 Very High Very High Very High
nMDA receptor 7 96.24 Very High Very High Very High
Central nervous system 3 95.36 Very High Very High Very High
Lasting pain 20 92.60 High High
Spinal cord 4 88.92 High High
Inflammation 9 87.44 High High
long-term potentiation 18 79.68 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 393 99.20 Very High Very High Very High
Pain 56 97.52 Very High Very High Very High
Targeted Disruption 597 96.48 Very High Very High Very High
INFLAMMATION 10 87.44 High High
Injury 14 86.76 High High
Nociception 6 82.16 Quite High
Nervous System Injury 6 77.36 Quite High
Neuropathic Pain 19 67.84 Quite High
Cognitive Disorder 48 38.32 Quite Low
Shock 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion of both AC1 and AC8 leads to deficits that result in an inability to maintain the CF memory, but this is rescued when AC8 is replaced within the forebrain of mice on a DKO background.
Localization (Deletion) of AC1 in forebrain associated with targeted disruption and anxiety disorder
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954788 Disease Relevance 0.74 Pain Relevance 0.03
At the cellular level, AC1 and AC8 are localized to the synapse, specifically the postsynaptic region for AC1 and presynaptic region for AC8 [11].
Localization (localized) of AC1 in synapse
2) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954788 Disease Relevance 0.71 Pain Relevance 0.15
AC1 and AC8 are both localized to brain regions known to play essential roles in memory processing, such as the cortex, cerebellum, and hippocampus [8], [9], [10].
Localization (localized) of AC1 in hippocampus associated with hippocampus
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954788 Disease Relevance 0.72 Pain Relevance 0.11
2.97 fc), reflecting the low abundance of AC1 in WT amygdala (?
Localization (abundance) of AC1 in amygdala associated with amygdala
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954788 Disease Relevance 0.82 Pain Relevance 0.34
To examine the roles of AC1 and AC8 in behavioral sensitization within the ACC, an area mediating the emotional component of pain, we used AC1 and AC8 knockout mice as well as AC1&8 double knockout (DKO) mice to determine the roles of these ACs in chronic pain [7] (Fig. 1).
Localization (sensitization) of AC1 associated with targeted disruption, pain, lasting pain and anterior cingulate cortex
5) Confidence 0.58 Published 2010 Journal Current Genomics Section Body Doc Link PMC2851120 Disease Relevance 1.51 Pain Relevance 0.77
AC1 and AC8 are both localized to brain regions known to play essential roles in memory processing, such as the cortex, cerebellum, and hippocampus [8], [9], [10].
Localization (localized) of AC1 in cerebellum associated with hippocampus
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954788 Disease Relevance 0.72 Pain Relevance 0.11
AC1 and AC8 are both localized to brain regions known to play essential roles in memory processing, such as the cortex, cerebellum, and hippocampus [8], [9], [10].
Localization (localized) of AC1 in cortex associated with hippocampus
7) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954788 Disease Relevance 0.72 Pain Relevance 0.11

General Comments

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