INT305137

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
gamete 1
p47 (Mamestra configurata NPV-B)
Pain Term Frequency Confidence Heat
Pain 4 33.00 Quite Low
Disease Term Frequency Confidence Heat
Targeted Disruption 24 99.74 Very High Very High Very High
Malaria 24 97.52 Very High Very High Very High
Infection 24 79.72 Quite High
Bites And Stings 8 74.72 Quite High
Pain 4 33.00 Quite Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Salivary Gland Disease 4 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Contagious Ecthyma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies demonstrate that P. berghei females lacking P47 are not recognized by wild type males.
Negative_regulation (lacking) of P47
1) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2851734 Disease Relevance 0 Pain Relevance 0
In order to determine which residues of p230, p47 and p48/45 genes were under positive selection in the rodent malaria parasites, a Bayes Empirical Bayes (BEB) analysis was performed using sequences from the 3 rodent genomes and was calculated as described in Yang et al. [49].
Negative_regulation (residues) of p47 associated with malaria
2) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2851734 Disease Relevance 0.10 Pain Relevance 0
p47 indicate that the few fertilisation events in single knock-out mutants deficient in expression of either P47 or P48/P45 (this study and [4]) cannot be explained by a compensation effect due to its paralogous protein because the ?
Negative_regulation (deficient) of P47 associated with targeted disruption
3) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2851734 Disease Relevance 0.42 Pain Relevance 0
Although we found that gametes lacking expression of these proteins did not show a significant reduction in fertilisation, the effect of their absence on gamete fertility may only become evident in the absence of P48/45, P47 and P230.
Negative_regulation (absence) of P47 in gamete
4) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2851734 Disease Relevance 0 Pain Relevance 0

General Comments

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