INT30517

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Context Info
Confidence 0.58
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 22
Disease Relevance 16.52
Pain Relevance 16.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
microglia 3
spinal cord 2
liver 1
vasculature 1
DRG 1
Bdkrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 1319 100.00 Very High Very High Very High
Spinal cord 280 100.00 Very High Very High Very High
antagonist 245 100.00 Very High Very High Very High
anesthesia 1 100.00 Very High Very High Very High
b2 receptor 4 99.80 Very High Very High Very High
intrathecal 133 99.70 Very High Very High Very High
fibrosis 7 99.56 Very High Very High Very High
Intracerebroventricular 1 99.18 Very High Very High Very High
bradykinin 283 99.14 Very High Very High Very High
agonist 182 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Internal Fibrosis 7 99.56 Very High Very High Very High
Insulin Resistance 98 99.52 Very High Very High Very High
Diabetes Mellitus 574 99.44 Very High Very High Very High
Targeted Disruption 28 99.36 Very High Very High Very High
Diabetes Complications 28 99.28 Very High Very High Very High
Pressure And Volume Under Development 134 99.00 Very High Very High Very High
Ganglion Cysts 13 98.58 Very High Very High Very High
Hyperalgesia 159 98.50 Very High Very High Very High
Pain 119 98.44 Very High Very High Very High
Pressure Volume 2 Under Development 4 98.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The coadministration of yohimbine or idazoxan with imipramine resulted in a decrease in beta-1 receptor function in only 4 days.
Negative_regulation (decrease) of beta-1 receptor
1) Confidence 0.58 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2868116 Disease Relevance 0.09 Pain Relevance 0.25
The coadministration of the selective alpha-2 antagonists, yohimbine or idazoxan (RX 781094), with imipramine resulted in a decrease in beta-1 receptor sensitivity in anesthetized rats within only 4 days.
Negative_regulation (decrease) of beta-1 receptor associated with antagonist
2) Confidence 0.58 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2868116 Disease Relevance 0.06 Pain Relevance 0.17
Prolonged inhibition of B1R with SSR240612 reversed hypertension, pain polyneuropathy and metabolic alterations in glucose-fed rats.
Negative_regulation (inhibition) of B1R associated with neuropathy, pain, pressure and volume under development and b1 receptor
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.12 Pain Relevance 0.42
The one-week treatment with 10 mg/kg SSR240612 reversed completely B1R mRNA overexpression in aorta and skeletal muscle and reduced significantly B1R mRNA level in the liver of glucose-fed rats.
Negative_regulation (reduced) of B1R mRNA in liver associated with b1 receptor
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.09 Pain Relevance 0.76
Renal expression of B2R is also significantly enhanced in B1R knockout mice [75], suggesting that the absence of one kinin receptor is compensated by the over-expression of the remaining kinin receptor.
Negative_regulation (absence) of kinin receptor associated with targeted disruption and b1 receptor
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.33 Pain Relevance 0.39
The inhibition of B1R had positive outcome on diabetic complications in the model of glucose-fed rat.
Negative_regulation (inhibition) of B1R associated with diabetes complications and b1 receptor
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.96 Pain Relevance 0.83
This study provides the first demonstration that the activation of B1R increased the oxidative stress through the activation of NADPH oxidase in the vasculature and that the sustained inhibition of B1R for one-week with SSR240612 reversed the oxidative stress and the subsequent B1R upregulation in a model of insulin resistance.
Negative_regulation (inhibition) of B1R in vasculature associated with stress, b1 receptor and insulin resistance
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.41 Pain Relevance 0.46
The lack of both kinin B1R and B2R enhances diabetic complications, including nephropathy and neuropathy in Akita diabetic mice [64].
Negative_regulation (lack) of kinin B1R associated with diabetes mellitus, diabetes complications, b1 receptor, neuropathic pain and renal disease
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.76 Pain Relevance 0.51
In isolated spontaneously beating right atria taken from drug-treated rats, beta-1 receptor sensitivity (isoproterenol positive chronotrophy) was not affected by the administration of imipramine for 4 days; however, administration of imipramine for 11 days resulted in significant decrease in beta-1 receptor sensitivity.
Negative_regulation (decrease) of beta-1 receptor
9) Confidence 0.42 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2868116 Disease Relevance 0.08 Pain Relevance 0.24
Beta-2 receptor sensitivity (isoproterenol-induced hypotension in anesthetized rats) was not significantly altered under conditions in which beta-1 receptor sensitivity was decreased.
Negative_regulation (decreased) of beta-1 receptor associated with pressure volume 2 under development
10) Confidence 0.42 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2868116 Disease Relevance 0.10 Pain Relevance 0.27
Autoradiography studies showed a widespread distribution of kinin B1R binding sites in the spinal cord of diabetic rats [19,21-23].
Negative_regulation (distribution) of B1R in spinal cord associated with diabetes mellitus, b1 receptor and spinal cord
11) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.56 Pain Relevance 1.44
This response was prevented by the inhibition of B1R (SSR240612, 10 ?
Negative_regulation (inhibition) of B1R associated with b1 receptor
12) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.34 Pain Relevance 1.40
Intrathecal or peripheral blockade of B1R or inhibition of microglia reversed time-dependently tactile and cold allodynia in diabetic rats without affecting basal values in control rats.
Negative_regulation (blockade) of B1R in microglia associated with allodynia, diabetes mellitus, b1 receptor and intrathecal
13) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2913947 Disease Relevance 1.55 Pain Relevance 1.61
g) was injected intrathecally to assess the specificity of B1R blockade on microglia.


Negative_regulation (blockade) of B1R in microglia associated with b1 receptor
14) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.09 Pain Relevance 0.55
The specific objectives were to: 1) determine whether microglia inhibitors can prevent thermal hyperalgesia and tactile allodynia induced by spinal activation of B1R with the selective agonist des-Arg9-BK in STZ-diabetic rats; 2) compare the acute inhibition of B1R and microglial function on tactile and cold allodynia; 3) determine the effect of microglia inhibition on the expression of B1R and pro-inflammatory markers (IL-1?
Negative_regulation (inhibition) of B1R in microglia associated with brush evoked pain, allodynia, diabetes mellitus, bradykinin, thermal hyperalgesia, b1 receptor, inflammatory marker and agonist
15) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.32 Pain Relevance 1.30
Our results also showed that systemic blockade of B1R with the peptide B1R antagonist R-715 reversed STZ-induced allodynia, supporting the idea that peripherally expressed B1R may also contribute to neuropathic pain.
Negative_regulation (blockade) of B1R associated with allodynia, antagonist, b1 receptor and neuropathic pain
16) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.22 Pain Relevance 1.71
Inhibition of beta-1 receptor but not vagotomy can abolish the L-NAME evoked bradycardia in anesthetized rat.
Negative_regulation (Inhibition) of beta-1 receptor associated with heart rate under development and anesthesia
17) Confidence 0.40 Published 2002 Journal Physiol Res Section Title Doc Link 12234113 Disease Relevance 0.35 Pain Relevance 0.13
Prolonged blockade of B1R restored cardiovascular, sensory and metabolic abnormalities by reducing oxidative stress and B1R gene expression in this model.



Negative_regulation (blockade) of B1R associated with stress, congenital anomalies and b1 receptor
18) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935380 Disease Relevance 0.87 Pain Relevance 0.62
For the first time, we demonstrated that acute blockade of spinal cord B1R with SSR240612 or R-715 can reverse both types of allodynia in STZ-diabetic rats.
Negative_regulation (blockade) of B1R in spinal cord associated with allodynia, diabetes mellitus, b1 receptor and spinal cord
19) Confidence 0.37 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.15 Pain Relevance 1.74
The expression of COX-2 induced by BK in DRG cells was inhibited by a BK B2 receptor antagonist, HOE140, but not a B1 receptor antagonist, Lys-des-Arg9, (Leu8)-BK.
Negative_regulation (antagonist) of B1 receptor in DRG associated with dorsal root ganglion, b1 receptor, antagonist, b2 receptor and bradykinin
20) Confidence 0.12 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16580130 Disease Relevance 0.36 Pain Relevance 1.09

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