INT305226

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 248 99.84 Very High Very High Very High
Obesity 338 96.80 Very High Very High Very High
Stress 34 56.32 Quite High
Lifespan 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 10 5.00 Very Low Very Low Very Low
Insulin Resistance 8 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Coronary Heart Disease 6 5.00 Very Low Very Low Very Low
Metabolic Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Short-term leptin treatment at physiological level (1.0 nM) reconciled
                   the reduced phosphorylation of Akt and eNOS in young ob/ob, but
                   not the aging mice. 
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of leptin associated with aging
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.87 Pain Relevance 0
Leptin at 1.0
                   nM reconciled the reduced ERK phosphorylation in aging ob/ob
                   mice without affecting any other mouse groups. 
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Leptin associated with aging
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.03 Pain Relevance 0

General Comments

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