INT305234

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 6 77.44 Quite High
alcohol 24 50.00 Quite Low
tolerance 12 39.04 Quite Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 173 99.50 Very High Very High Very High
Aging 124 98.20 Very High Very High Very High
Neurodegenerative Disease 2 80.80 Quite High
Diabetes Mellitus 9 78.48 Quite High
Cv Unclassified Under Development 6 77.44 Quite High
Hepatocellular Cancer 2 57.20 Quite High
Stress 25 50.00 Quite Low
Coronary Heart Disease 11 50.00 Quite Low
Impaired Glucose Tolerance 20 39.04 Quite Low
Apoptosis 5 14.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In line with its effect on AMPK and ACC phosphorylation, acute ethanol challenge enhanced the phosphorylation of LKB1 (both absolute and pLKB1/LKB1 ratio), the effect of which was augmented by ADH transgene.
Regulation (effect) of Phosphorylation (phosphorylation) of AMPK
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Our findings suggest that the phosphorylation of AMPK at Thr172 may be influenced by the expression of PP2A but less likely PP2C?
Spec (may) Regulation (influenced) of Phosphorylation (phosphorylation) of AMPK
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.29 Pain Relevance 0.04
While obesity and age alone failed to affect AMPK and its
                   phosphorylation, the combination of the two significantly attenuated AMPK
                   phosphorylation but not total AMPK expression. 
Neg (failed) Regulation (affect) of Phosphorylation (phosphorylation) of AMPK associated with obesity
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.77 Pain Relevance 0

General Comments

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