INT305235

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.17
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
brains 2
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 86.44 High High
Inflammation 8 86.04 High High
imagery 57 30.64 Quite Low
Hippocampus 30 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 676 99.98 Very High Very High Very High
Disease 223 99.28 Very High Very High Very High
Aging 508 99.26 Very High Very High Very High
Hypoxia 3 88.04 High High
INFLAMMATION 8 86.04 High High
Stress 107 75.00 Quite High
Amyloid Plaque 9 39.28 Quite Low
Lifespan 24 23.04 Low Low
Myocardial Infarction 8 19.20 Low Low
Diabetes Mellitus 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction of mitochondrial superoxide also resulted in a concomitant reduction of phosphorylation of eNOS at serine 1177, as well as phosphorylation of tau at serine 262.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of eNOS
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.15 Pain Relevance 0
We also demonstrated that Tg2576 mice exhibit an increased phosphorylation of eNOS at serine 1177. eNOS expression has been shown to be decreased in the brains of AD patients [44].
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of eNOS in brains associated with disease
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.40 Pain Relevance 0
The reduction of mitochondrial superoxide also resulted in a concomitant reduction of phosphorylation of eNOS at serine 1177, as well as phosphorylation of tau at serine 262.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of eNOS
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.15 Pain Relevance 0
Interestingly, short-term treatment of
                   leptin at pharmacological level (50 nM) significantly suppressed the
                   phosphorylation of Akt, eNOS and AMPK in all mouse groups (with the exception of
                   AMPK phosphorylation in aging ob/ob group) without affecting the expression of
                   non-phosphorylated Akt, eNOS and AMPK (Fig. 7).


Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of eNOS associated with aging
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.84 Pain Relevance 0
B) in aging and
               obesity are consistent with the reduced phosphorylation of Akt and eNOS. 
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of eNOS associated with aging and obesity
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.88 Pain Relevance 0.09
Aging and
                       obesity reduced phosphorylation of Akt, eNOS and p38 while promoting pJNK
                       and pI?
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of eNOS associated with aging and obesity
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852499 Disease Relevance 0.97 Pain Relevance 0
Short-term leptin treatment at physiological level (1.0 nM) reconciled
                   the reduced phosphorylation of Akt and eNOS in young ob/ob, but
                   not the aging mice. 
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of eNOS associated with aging
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.79 Pain Relevance 0

General Comments

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