INT305244

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Leprot) Golgi apparatus (Leprot)
Anatomy Link Frequency
brain 2
Leprot (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 372 99.28 Very High Very High Very High
Obesity 507 97.96 Very High Very High Very High
Stress 51 71.52 Quite High
Lifespan 18 5.00 Very Low Very Low Very Low
Diabetes Mellitus 15 5.00 Very Low Very Low Very Low
Insulin Resistance 12 5.00 Very Low Very Low Very Low
Death 12 5.00 Very Low Very Low Very Low
Body Weight 12 5.00 Very Low Very Low Very Low
Coronary Heart Disease 9 5.00 Very Low Very Low Very Low
Metabolic Syndrome 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, short-term leptin supplementation at both 1.0
                   nM and 50 nM significantly upregulated Ob-R expression in young but not aging
                       ob/ob mice and stimulated STAT-3 phosphorylation in both
                   young and aging ob/ob groups. 
Positive_regulation (upregulated) of Gene_expression (expression) of Ob-R associated with aging and obesity
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.90 Pain Relevance 0
Interestingly, short-term leptin supplementation at both 1.0
                   nM and 50 nM significantly upregulated Ob-R expression in young but not aging
                       ob/ob mice and stimulated STAT-3 phosphorylation in both
                   young and aging ob/ob groups. 
Positive_regulation (upregulated) of Gene_expression (expression) of Ob-R associated with aging and obesity
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.90 Pain Relevance 0
The leptin-induced
               STAT-3 phosphorylation was found to be higher along with an upregulated hypothalamic
               expression of the Ob-R at 14 - 18 months of mouse age compared with 2 months of age
                   [41],
               indicating increased leptin sensitivity with aging in the mouse brain. 
Positive_regulation (upregulated) of Gene_expression (expression) of Ob-R in brain associated with aging
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.48 Pain Relevance 0

General Comments

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