INT305245

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Anatomy Link Frequency
adipocytes 2
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 12 50.00 Quite Low
ischemia 3 37.12 Quite Low
tolerance 6 27.12 Quite Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 171 99.52 Very High Very High Very High
Aging 124 94.28 High High
Toxicity 7 51.92 Quite High
Stress 21 50.00 Quite Low
Coronary Heart Disease 7 50.00 Quite Low
Alcoholic Cardiomyopathy 4 39.60 Quite Low
Diabetes Mellitus 7 38.44 Quite Low
Reperfusion Injury 1 38.04 Quite Low
Cv Unclassified Under Development 3 37.12 Quite Low
Injury 1 32.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although long-term ethanol exposure is known to inhibit Glut4 expression via an AMPK-dependent pathway in adipocytes [29], our current data were unable to address the intimate interplay among AMPK signaling, insulin sensitivity, myocardial and intracellular Ca2+ derangement following acute ethanol exposure.
Negative_regulation (inhibit) of Gene_expression (expression) of AMPK-dependent in adipocytes associated with obesity
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.15 Pain Relevance 0
While obesity and age alone failed to affect AMPK and its
                   phosphorylation, the combination of the two significantly attenuated AMPK
                   phosphorylation but not total AMPK expression. 
Negative_regulation (attenuated) of Gene_expression (expression) of AMPK associated with obesity
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.80 Pain Relevance 0

General Comments

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