INT305306

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.79
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina5) extracellular region (Serpina5) protein complex (Serpina5)
Anatomy Link Frequency
lung 8
tubules 4
thorax 3
intercostal muscles 1
Serpina5 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 18 60.56 Quite High
alcohol 27 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Corneal Neovascularization 9 83.72 Quite High
Cancer 9 80.08 Quite High
Male Infertility 9 75.28 Quite High
Stress Incontinence 45 69.48 Quite High
Hypertrophy 9 49.64 Quite Low
Apoptosis 63 5.00 Very Low Very Low Very Low
Hypersensitivity 27 5.00 Very Low Very Low Very Low
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Thrombosis 9 5.00 Very Low Very Low Very Low
Thrombosis Related Under Development 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCI expression declined in postnatal stages and was not detected in adult lungs.
Negative_regulation (declined) of Gene_expression (expression) of PCI in lungs
1) Confidence 0.51 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
In addition, PCI expression could be detected in the muscles of the thorax, intercostal muscles and in the diaphragm (Fig. 3c, e, h).
Negative_regulation (detected) of Gene_expression (expression) of PCI in thorax
2) Confidence 0.37 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.14 Pain Relevance 0.03
Several putative functions for PCI in the developing mouse lung can be postulated: (1) PCI is directly involved in lung morphogenesis participating in branching of the bronchiolar tree by controlling extracellular proteolysis; (2) PCI is secreted into amniotic fluid and the lung may represent a source of PCI production and secretion into the amniotic fluid; (3) PCI could act through interaction with HGF which is expressed in lung mesenchyme (Sonnenberg et al. 1993); (4) notably, PCI expression could not be detected in the epithelia responsible for gas exchange in sacculi and alveoli at later stages of development.
Negative_regulation (source) of Gene_expression (source) of PCI in lung
3) Confidence 0.37 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.13 Pain Relevance 0
PCI expression declined in postnatal stages and was not detected in adult lungs.
Negative_regulation (declined) of Gene_expression (expression) of PCI in lungs
4) Confidence 0.37 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
Conversely, expression of PCI in cuboidal epithelia of bronchi and bronchioli may help to prevent this process.
Negative_regulation (prevent) of Gene_expression (expression) of PCI
5) Confidence 0.37 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.24 Pain Relevance 0
In the pseudoglandular stage, PCI expression was present in distal branching tubules whereas proximal tubules did not express PCI.
Negative_regulation (present) of Neg (not) Gene_expression (express) of PCI in tubules
6) Confidence 0.37 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
In the pseudoglandular stage, PCI expression was present in distal branching tubules whereas proximal tubules did not express PCI.
Negative_regulation (present) of Gene_expression (expression) of PCI in tubules
7) Confidence 0.37 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
Several putative functions for PCI in the developing mouse lung can be postulated: (1) PCI is directly involved in lung morphogenesis participating in branching of the bronchiolar tree by controlling extracellular proteolysis; (2) PCI is secreted into amniotic fluid and the lung may represent a source of PCI production and secretion into the amniotic fluid; (3) PCI could act through interaction with HGF which is expressed in lung mesenchyme (Sonnenberg et al. 1993); (4) notably, PCI expression could not be detected in the epithelia responsible for gas exchange in sacculi and alveoli at later stages of development.
Negative_regulation (source) of Gene_expression (production) of PCI in lung
8) Confidence 0.37 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.14 Pain Relevance 0
In addition, PCI expression could be detected in the muscles of the thorax, intercostal muscles and in the diaphragm (Fig. 3c, e, h).
Negative_regulation (detected) of in intercostal muscles Gene_expression (expression) of PCI in thorax
9) Confidence 0.13 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.14 Pain Relevance 0.03

General Comments

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