INT305307

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 7
Speculated 0
Reported most in Body
Documents 88
Total Number 89
Disease Relevance 10.09
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina5) extracellular region (Serpina5) protein complex (Serpina5)
Anatomy Link Frequency
lung 15
tubules 6
skin 5
urethra 4
duct 3
Serpina5 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 174 99.18 Very High Very High Very High
alcohol 261 92.84 High High
anesthesia 87 78.60 Quite High
Inflammatory response 4 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 89 99.88 Very High Very High Very High
Stress Incontinence 435 99.84 Very High Very High Very High
Apoptosis 609 99.24 Very High Very High Very High
Hypertension 87 96.92 Very High Very High Very High
Volume Depletion And Dehydration 87 92.04 High High
Metastasis 87 90.16 High High
Breast Cancer 87 89.20 High High
Thrombosis Related Under Development 87 87.20 High High
Death 87 86.00 High High
Cancer 87 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some sites of PCI expression suggest its involvement in the proteolysis of extracellular matrix in connection with morphogenetic processes and/or angiogenesis.
Gene_expression (expression) of PCI in extracellular matrix
1) Confidence 0.78 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.17 Pain Relevance 0
Other sites of PCI expression are more difficult to reconcile with known functions of PCI.
Gene_expression (expression) of PCI
2) Confidence 0.78 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.38 Pain Relevance 0
We studied a minimum of 3 animals per time-point.Fig. 1Controls for detection of PCI expression in lung tissue at embryonic days (ED) 14.5 (a–d) and 16.5 (e–h), respectively.
Gene_expression (expression) of PCI in lung
3) Confidence 0.78 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.18 Pain Relevance 0.04
PCI expression ceases in the perinatal period and is undetectable in adult lungs.
Gene_expression (expression) of PCI in lungs
4) Confidence 0.78 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.06 Pain Relevance 0
Further sites of PCI expression were choroid plexus of brain ventricles, heart, skeletal muscles, urogenital tract, and cartilages.
Gene_expression (expression) of PCI in skeletal muscles
5) Confidence 0.78 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
Other sites of PCI expression may suggest a role for PCI in developmentally important cellular processes such as growth factor signaling.


Gene_expression (expression) of PCI
6) Confidence 0.78 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.26 Pain Relevance 0
Several putative functions for PCI in the developing mouse lung can be postulated: (1) PCI is directly involved in lung morphogenesis participating in branching of the bronchiolar tree by controlling extracellular proteolysis; (2) PCI is secreted into amniotic fluid and the lung may represent a source of PCI production and secretion into the amniotic fluid; (3) PCI could act through interaction with HGF which is expressed in lung mesenchyme (Sonnenberg et al. 1993); (4) notably, PCI expression could not be detected in the epithelia responsible for gas exchange in sacculi and alveoli at later stages of development.
Gene_expression (expression) of PCI in lung
7) Confidence 0.78 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.16 Pain Relevance 0
Thus, we mapped the expression pattern of PCI mRNA and protein throughout mouse development.
Gene_expression (expression) of PCI mRNA
8) Confidence 0.78 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
In this study, we mapped the expression pattern of PCI throughout mouse development using in situ hybridization and immunohistochemistry.
Gene_expression (expression) of PCI
9) Confidence 0.68 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
Several putative functions for PCI in the developing mouse lung can be postulated: (1) PCI is directly involved in lung morphogenesis participating in branching of the bronchiolar tree by controlling extracellular proteolysis; (2) PCI is secreted into amniotic fluid and the lung may represent a source of PCI production and secretion into the amniotic fluid; (3) PCI could act through interaction with HGF which is expressed in lung mesenchyme (Sonnenberg et al. 1993); (4) notably, PCI expression could not be detected in the epithelia responsible for gas exchange in sacculi and alveoli at later stages of development.
Gene_expression (source) of PCI in lung
10) Confidence 0.68 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.13 Pain Relevance 0
Later in development, in the saccular stage, PCI expression was restricted to distal bronchioli whereas sacculi did not express PCI.
Gene_expression (expression) of PCI
11) Confidence 0.68 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
In the saccular phase, PCI is expressed in the bronchiolar epithelia and is absent from saccular epithelia.
Neg (absent) Gene_expression (expressed) of PCI
12) Confidence 0.68 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.07 Pain Relevance 0
The embryonic and fetal expression pattern of PCI suggests involvement in different developmental processes.
Gene_expression (expression) of PCI
13) Confidence 0.68 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
In the pseudoglandular stage, PCI expression was present in distal branching tubules whereas proximal tubules did not express PCI.
Gene_expression (expression) of PCI in tubules
14) Confidence 0.68 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
This approach likely resulted in a superior level of sensitivity of immunohistochemistry over in situ hybridization which may explain the discrepancy in detection of the temporal onset of PCI expression using the two methods.
Gene_expression (expression) of PCI in superior
15) Confidence 0.68 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
On ED 14.5–16.5 in the cranial region PCI was expressed in the developing brain in the choroid plexus (Fig. 3a), in the epithelial lining of the nasal and oral cavities and in the skin of the nose including developing vibrissae (Fig. 3b).
Gene_expression (expressed) of PCI in vibrissae
16) Confidence 0.68 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.16 Pain Relevance 0.07
In the abdominal region, PCI expression was largely absent from liver and pancreas (Fig. 4a).
Neg (absent) Gene_expression (expression) of PCI in liver
17) Confidence 0.68 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.14 Pain Relevance 0.03
A strong and stage-dependent PCI expression was observed in the developing lung.
Gene_expression (expression) of PCI in lung
18) Confidence 0.68 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
Since highest PCI expression was observed in the developing embryonic lung, only lung tissue was studied in ED 18.5, neonatal days 1 and 2, and adult mice.


Gene_expression (expression) of PCI in lung
19) Confidence 0.68 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.26 Pain Relevance 0.13
In the pseudoglandular stage, PCI expression was present in distal branching tubules whereas proximal tubules did not express PCI.
Neg (not) Gene_expression (express) of PCI in tubules
20) Confidence 0.68 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0

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