INT30531

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Context Info
Confidence 0.66
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 5.50
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular region (C2)
Anatomy Link Frequency
whisker 2
articulation 1
lateral 1
posterior 1
synovium 1
C2 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 67 99.84 Very High Very High Very High
Inflammation 50 99.20 Very High Very High Very High
Hippocampus 282 98.12 Very High Very High Very High
abdominal pain 2 95.36 Very High Very High Very High
long-term potentiation 104 91.84 High High
imagery 45 90.88 High High
nMDA receptor 520 85.52 High High
Antihistamine 4 83.40 Quite High
corticosteroid 1 81.48 Quite High
Facet joint 15 80.72 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 76 99.84 Very High Very High Very High
Disease 80 99.42 Very High Very High Very High
INFLAMMATION 56 99.20 Very High Very High Very High
Comminuted Fractures 5 98.72 Very High Very High Very High
Pressure And Volume Under Development 22 97.96 Very High Very High Very High
Cancer 8 97.60 Very High Very High Very High
Injury 148 97.48 Very High Very High Very High
Asphyxia 1 96.76 Very High Very High Very High
Vomiting 2 96.08 Very High Very High Very High
Abdominal Pain 2 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Change in dosage required to maintain C2 levels at each visit was analyzed by paired sample t-test.
Gene_expression (levels) of C2
1) Confidence 0.66 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721520 Disease Relevance 0.55 Pain Relevance 0.14
Furthermore, positive correlations have been shown between SF complement activation (for example levels of plasma C3dg, a C3 activation metabolite) and local as well as general disease activity in RA, and between C2 and C3 expression in RA synovium and inflammation [19,20].
Gene_expression (expression) of C2 in synovium associated with inflammation, rheumatoid arthritis and disease
2) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.48 Pain Relevance 0.52
mice but a C2 fragment is not detectable in C4/?
Neg (not) Gene_expression (detectable) of C2
3) Confidence 0.31 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.07 Pain Relevance 0.03
The mean distance between C2 and neighboring whisker representations averaged across both arcs and rows of the barrel map was 359?
Gene_expression (distance) of C2 in whisker
4) Confidence 0.29 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0 Pain Relevance 0.11
The full-length CAPS2 protein consists of the following functional domains, as shown in Figure 2: a dynactin 1-interacting domain (DID), a C2 domain, a pleckstrin homology (PH) domain and a Munc13-1-homologous domain (MHD).
Gene_expression (domain) of C2
5) Confidence 0.28 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0
Quantifying the spatial extent of the intrinsic optical signal, the location of the peak response from C1, C2, and C3 whiskers can be easily distinguished, separated by 243??
Gene_expression (whiskers) of C2 in whiskers
6) Confidence 0.15 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0 Pain Relevance 0.11
Propagation of complement activation by the C3 convertase results in the generation of a C5 convertase on cell surfaces.
Gene_expression (generation) of C5 convertase
7) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.14 Pain Relevance 0.04
The C2 cassette contains a translational stop codon and, in its absence, an additional sequence with the next stop codon, known as the C2?
Gene_expression (cassette) of C2
8) Confidence 0.10 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0 Pain Relevance 0.12
The designations for the C terminal splice variants are GluN1X11 (GluN1-1:C1,C2 cassettes), GluN1X01 (GluN1-2:C2 cassette), GluN1X10 (GluN1-3: C1, C2?
Gene_expression (designations) of C2
9) Confidence 0.10 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0 Pain Relevance 0.12
The designations for the C terminal splice variants are GluN1X11 (GluN1-1:C1,C2 cassettes), GluN1X01 (GluN1-2:C2 cassette), GluN1X10 (GluN1-3: C1, C2?
Gene_expression (cassette) of C2
10) Confidence 0.10 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0 Pain Relevance 0.12
This is associated with a decline in protein expression of the C2 cassettes of the GluN1 subunit (Clayton et al., 2002a).
Gene_expression (expression) of C2
11) Confidence 0.09 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.35 Pain Relevance 0.12
Diagnosis can be confirmed by the finding of low levels of C4 and C2 and the absence of nonfunction of C1INH.
Gene_expression (levels) of C2
12) Confidence 0.07 Published 1985 Journal Dermatol Clin Section Abstract Doc Link 2868818 Disease Relevance 1.54 Pain Relevance 0.29
Subjects who had pathology of the C1-C2 facets and C1 lateral masses, such as comminuted fractures or the tumors destroying the C1 lateral masses that preclude screw placement were excluded from the study.
Gene_expression (facets) of C2 in lateral associated with comminuted fractures and cancer
13) Confidence 0.05 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2995783 Disease Relevance 0.20 Pain Relevance 0.09
We did not use the morselized graft but a strut of iliac crest graft well fitted in the space between the C1 lamina and C2 spinous process.
Gene_expression (spinous process) of C2 in iliac
14) Confidence 0.05 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2995783 Disease Relevance 0.38 Pain Relevance 0.10
The biomechanics of surgical stabilization of the C1-C2 articulation can be divided into three different types.
Gene_expression (articulation) of C2 in articulation
15) Confidence 0.05 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2995783 Disease Relevance 0 Pain Relevance 0.04
In one, the compression was from the back only (so posterior decompression and C0-C2 fusion with contoured rod fixation was done) while in the other, compression was from the front and back (so anterior transoral decompression/odontoidectomy with posterior C0-C2 fusion with contoured rod fixation was done in the same sitting).
Gene_expression (decompression) of C2 in posterior
16) Confidence 0.04 Published 2007 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2989524 Disease Relevance 0.59 Pain Relevance 0.04
Axis (C2) fractures
Gene_expression (Axis) of C2
17) Confidence 0.04 Published 2007 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2989524 Disease Relevance 0.21 Pain Relevance 0

General Comments

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