INT305310

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina5) extracellular region (Serpina5) protein complex (Serpina5)
Anatomy Link Frequency
lung 6
Serpina5 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 12 5.00 Very Low Very Low Very Low
Bile 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 99.88 Very High Very High Very High
Hypertension 4 95.96 Very High Very High Very High
Thrombosis 4 67.36 Quite High
Hypertrophy 4 64.76 Quite High
Thrombosis Related Under Development 4 64.32 Quite High
Cancer 4 39.20 Quite Low
Corneal Neovascularization 4 33.12 Quite Low
Metastasis 4 30.92 Quite Low
Breast Cancer 4 29.96 Quite Low
Apoptosis 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In transgenic mice overexpressing PCI in multiple organs, including the lung, the role of PCI in protection against monocrotaline-induced pulmonary hypertension was described (Nishii et al. 2006).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PCI in lung associated with targeted disruption and hypertension
1) Confidence 0.60 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.33 Pain Relevance 0
A strong and stage-dependent PCI expression was observed in the developing lung.
Positive_regulation (dependent) of Gene_expression (expression) of PCI in lung
2) Confidence 0.60 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
PCI expression ceases in the perinatal period and is undetectable in adult lungs.
Positive_regulation (ceases) of Gene_expression (expression) of PCI in lungs
3) Confidence 0.50 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.06 Pain Relevance 0
Later in development, in the saccular stage, PCI expression was restricted to distal bronchioli whereas sacculi did not express PCI.
Positive_regulation (restricted) of Gene_expression (expression) of PCI
4) Confidence 0.41 Published 2010 Journal J Mol Histol Section Abstract Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0

General Comments

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