INT305312

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.85
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina5) extracellular region (Serpina5) protein complex (Serpina5)
Anatomy Link Frequency
plasma 1
lung 1
Serpina5 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 8 78.24 Quite High
Inflammation 4 47.20 Quite Low
alcohol 6 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 124 99.52 Very High Very High Very High
Corneal Neovascularization 2 91.44 High High
Cancer 2 87.80 High High
Suicidal Behaviour 2 85.88 High High
Coronary Artery Disease 18 71.12 Quite High
Male Infertility 2 54.40 Quite High
Breast Cancer 2 52.48 Quite High
Metastasis 2 50.32 Quite High
INFLAMMATION 4 47.20 Quite Low
Pressure Volume 2 Under Development 2 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, down-regulation of PCI in alveoli could be necessary for alveolar capillarisation, a hallmark of saccular phase of lung development and crucial for proper post-natal lung functionality.
Regulation (regulation) of PCI in lung
1) Confidence 0.39 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.23 Pain Relevance 0
PCI is a multifunctional serpin that can act both as a protease inhibitor of the coagulation (activated protein C, factor Xa, factor XIa, protein Z-dependent protease inhibitor and plasma kallikrein), the fibrinolytic (urokinase-type plasminogen activator (uPA) and tissue-type PA (tPA)), and the fertilization system (acrosin and prostate specific antigen) (Christensson and Lilja 1994; Ecke et al. 1992; Espana et al. 1989; Geiger et al. 1989; Marlar and Griffin 1980; Meijers et al. 1988; Suzuki et al. 1983; Zheng et al. 1994).
Regulation (act) of PCI in plasma
2) Confidence 0.24 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.19 Pain Relevance 0
Twenty patients suffered from a definite late or very late stent thrombosis within the last 43 (median 10) months and there were 32 PCI controls without (V)LST (median follow-up time 15 months).
Regulation (controls) of PCI associated with thrombosis
3) Confidence 0.01 Published 2010 Journal Thromb J Section Body Doc Link PMC2871266 Disease Relevance 0.45 Pain Relevance 0.14
The study was a single-centre cohort study (Risk markers for Late in Stent Thrombosis (RIST)), in which 20 patients with a history of definitive (V)LST (as proposed by the Academic Research Consortium [32]) were compared to 32 PCI controls without (V)LST.
Regulation (controls) of PCI associated with thrombosis
4) Confidence 0.01 Published 2010 Journal Thromb J Section Body Doc Link PMC2871266 Disease Relevance 0.98 Pain Relevance 0

General Comments

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