INT305315

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.52
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
monocyte 2
platelet 2
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 70 99.98 Very High Very High Very High
cytokine 12 98.28 Very High Very High Very High
Arthritis 1 80.00 Quite High
metalloproteinase 4 70.04 Quite High
fibrosis 1 66.24 Quite High
ischemia 5 59.04 Quite High
Inflammatory response 6 11.16 Low Low
imagery 24 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 73 99.98 Very High Very High Very High
Myocardial Infarction 37 99.98 Very High Very High Very High
Thrombosis 1 94.16 High High
Thrombosis Related Under Development 1 92.64 High High
Arthritis 1 80.00 Quite High
Apoptosis 9 75.40 Quite High
Heart Rate Under Development 1 73.24 Quite High
Necrosis 2 67.48 Quite High
Cancer 3 67.12 Quite High
Fibrosis 1 66.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, the functional role in vivo was tested in venous thrombosis, where elevated levels of PCI constituted a mild risk factor for thrombosis (Meijers et al. 2002) indicating that of the possible actions of PCI: anticoagulant by inhibition of coagulation enzymes, anti-antifibrinolytic by inhibition of the thrombin activatable fibrinolysis inhibitor (TAFI) activation by thrombin-thrombomodulin, anti-anticoagulant by inhibition of activated protein C and protein C activation by thrombomodulin, and antifibrinolytic by the inhibition of urokinase, the last two options predominate in vivo.
Positive_regulation (activated) of Positive_regulation (activation) of protein C and protein C associated with thrombosis related under development and thrombosis
1) Confidence 0.49 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.40 Pain Relevance 0
Equally, anti-inflammatory effects of PC as well as LPC could be proofed by the downregulation of pro-inflammatory cytokines such as IL-8, monocyte chemotactic protein-1 (MCP-1) and interferon ?
Positive_regulation (proofed) of Positive_regulation (effects) of PC in monocyte associated with inflammation and cytokine
2) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.46 Pain Relevance 0.28
Intramyocardial transplantation of EPC after AMI induces significant and sustained increase in angiogenic, antiapoptotic, and chemoattractant factors, that are upregulated in both transplanted and host cells (i.e., vascular endothelial growth factor-A [VEGF-A], fibroblast growth factor-2 [FGF-2], angiopoietin-1 [Ang-1], angiopoietin-2 [Ang-2], placenta growth factor [PIGF], hepatocyte growth factor [HGF], insulin-like growth factor-1 [IGF-1], platelet-derived growth factor-B [PDGF-B], and stromal cell-derived factor-1 [SDF-1]) [35].
Positive_regulation (induces) of Positive_regulation (increase) of factors in platelet associated with myocardial infarction
3) Confidence 0.00 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2975079 Disease Relevance 0.65 Pain Relevance 0.36

General Comments

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