INT305316
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Further possible functions of PCI in the developing skin might involve protection from active proteases present in the amniotic fluid, such as uPA and tPA (Verkleij-Hagoort et al. 2007), or regulation of morphogen or growth factor supply in the epidermis, as PCI binds retinoids (Jerabek et al. 2001) and hepatocyte growth factor (HGF) both present in developing skin and amniotic fluid (Laurell et al. 1992; Srivastava et al. 1999). | |||||||||||||||
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Several putative functions for PCI in the developing mouse lung can be postulated: (1) PCI is directly involved in lung morphogenesis participating in branching of the bronchiolar tree by controlling extracellular proteolysis; (2) PCI is secreted into amniotic fluid and the lung may represent a source of PCI production and secretion into the amniotic fluid; (3) PCI could act through interaction with HGF which is expressed in lung mesenchyme (Sonnenberg et al. 1993); (4) notably, PCI expression could not be detected in the epithelia responsible for gas exchange in sacculi and alveoli at later stages of development. | |||||||||||||||
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Additionally, PCI might play a role via interaction with HGF which has also been shown to be involved in myoblast migration and muscle formation (Dietrich et al. 1999). | |||||||||||||||
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General Comments
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