INT305316

Context Info Confidence 0.21 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.00 Pain Relevance 0

extracellular space (Hgf, Serpina5) cell proliferation (Hgf) extracellular region (Serpina5) cell morphogenesis (Hgf) protein complex (Serpina5)

Anatomy Link Frequency myoblast 1 hepatocyte 1 lung 1 Hgf (Mus musculus) Serpina5 (Mus musculus)

Pain Link Frequency Relevance Heat alcohol 9 5.00 Bile 6 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 21 86.96 Cancer 3 76.56 Death 3 75.68 Corneal Neovascularization 3 70.48 Hypertrophy 3 46.92 Stress Incontinence 15 5.00 Hypersensitivity 9 5.00 Sprains And Strains 6 5.00 Thrombosis 3 5.00 Thrombosis Related Under Development 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further possible functions of PCI in the developing skin might involve protection from active proteases present in the amniotic fluid, such as uPA and tPA (Verkleij-Hagoort et al. 2007), or regulation of morphogen or growth factor supply in the epidermis, as PCI binds retinoids (Jerabek et al. 2001) and hepatocyte growth factor (HGF) both present in developing skin and amniotic fluid (Laurell et al. 1992; Srivastava et al. 1999).

HGF Binding (binds) of PCI in hepatocyte

1) Confidence 0.21 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.28 Pain Relevance 0

Several putative functions for PCI in the developing mouse lung can be postulated: (1) PCI is directly involved in lung morphogenesis participating in branching of the bronchiolar tree by controlling extracellular proteolysis; (2) PCI is secreted into amniotic fluid and the lung may represent a source of PCI production and secretion into the amniotic fluid; (3) PCI could act through interaction with HGF which is expressed in lung mesenchyme (Sonnenberg et al. 1993); (4) notably, PCI expression could not be detected in the epithelia responsible for gas exchange in sacculi and alveoli at later stages of development.

HGF Binding (interaction) of PCI in lung

2) Confidence 0.20 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.15 Pain Relevance 0

Additionally, PCI might play a role via interaction with HGF which has also been shown to be involved in myoblast migration and muscle formation (Dietrich et al. 1999).

HGF Spec (might) Binding (interaction) of PCI in myoblast

3) Confidence 0.20 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.58 Pain Relevance 0

General Comments

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