INT30532

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Context Info
Confidence 0.43
First Reported 1985
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.90
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
ovary 1
DFP (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 1 98.64 Very High Very High Very High
Morphine 4 95.36 Very High Very High Very High
Pain 5 94.84 High High
Inflammation 2 94.48 High High
rapifen 5 94.16 High High
Antinociceptive 2 93.28 High High
opioid receptor 1 92.44 High High
tetrodotoxin 1 91.64 High High
antinociception 2 90.72 High High
Action potential 1 87.72 High High
Disease Link Frequency Relevance Heat
Pain 5 94.84 High High
INFLAMMATION 2 94.48 High High
Drug Induced Neurotoxicity 1 89.28 High High
Poisoning 3 84.76 Quite High
Toxicity 7 68.16 Quite High
Iron Overload 18 60.92 Quite High
Depression 1 58.52 Quite High
Thalassemia 21 55.72 Quite High
Death 2 19.40 Low Low
Agranulocytosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potentiating activity of DFP was unaffected by atropine, pralidoxime and diazepam.
Neg (unaffected) Negative_regulation (unaffected) of DFP
1) Confidence 0.43 Published 1988 Journal Neurotoxicol Teratol Section Abstract Doc Link 3147363 Disease Relevance 0.32 Pain Relevance 0.96
DFP appears to be rapidly and completely absorbed after oral administration, with peak plasma levels typically occurring about 1 hour after administration.
Negative_regulation (absorbed) of DFP in plasma
2) Confidence 0.24 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.12 Pain Relevance 0
DFP [3-(2-propyloxy)-(4-methyl-sulfonylphenyl)-(5,5-dimethyl)-fu ranone] is a highly specific cyclooxygenase-2 inhibitor (>2500-fold selective in transfected Chinese hamster ovary cell assays) that has demonstrated efficacy in preclinical models of pain and inflammation.
Negative_regulation (inhibitor) of DFP in ovary associated with pain and inflammation
3) Confidence 0.18 Published 1999 Journal Clin Ther Section Abstract Doc Link 10485502 Disease Relevance 0.33 Pain Relevance 0.45
Physostigmine and some irreversible ChE inhibitors (VX and DFP) also blocked the postjunctional glutamate receptors.
Negative_regulation (inhibitors) of DFP associated with glutamate receptor
4) Confidence 0.02 Published 1985 Journal Fundam Appl Toxicol Section Abstract Doc Link 2868960 Disease Relevance 0.13 Pain Relevance 0.29

General Comments

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