INT305335

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.60
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Akr1b3) oxidoreductase activity (Akr1b3) nucleus (Akr1b3)
cytoplasm (Akr1b3)
Olfr927-ps1 (Mus musculus)
Akr1b3 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 1 99.28 Very High Very High Very High
Inflammation 5 98.48 Very High Very High Very High
tolerance 3 77.12 Quite High
Inflammatory response 1 29.84 Quite Low
Peripheral nervous system 6 27.52 Quite Low
Spinal cord 14 5.00 Very Low Very Low Very Low
Sciatic nerve 12 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
diabetic neuropathy 7 5.00 Very Low Very Low Very Low
hypoalgesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 98.48 Very High Very High Very High
Metabolic Syndrome 9 96.96 Very High Very High Very High
Stress 13 96.00 Very High Very High Very High
Diabetes Mellitus 17 95.64 Very High Very High Very High
Neuropathic Pain 24 94.64 High High
Hyperinsulinism 1 80.24 Quite High
Prediabetic State 6 80.04 Quite High
Impaired Glucose Tolerance 3 78.48 Quite High
Hyperglycemia 6 55.32 Quite High
Amputation 2 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PMI-5011 [16, 17], an ethanolic extract of Artemisia dracunculus L. with a good safety profile [16], has been found to inhibit activity of aldose reductase [18], the first enzyme of the sorbitol pathway, known to play an important role in the pathogenesis of both diabetic and prediabetic neuropathy [6, 19–23].
PMI-5011 Negative_regulation (inhibit) of aldose reductase associated with diabetes mellitus and neuropathic pain
1) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2852597 Disease Relevance 1.60 Pain Relevance 0.17

General Comments

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