INT305336

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TP53, RB1) DNA binding (TP53, RB1) nucleus (TP53, RB1)
transcription factor binding (TP53, RB1) cell differentiation (TP53) mitochondrion (TP53)
TP53 (Homo sapiens)
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 98.92 Very High Very High Very High
Endometroid Carcinoma 12 94.04 High High
Cancer 60 88.32 High High
Carcinoma 9 80.28 Quite High
Hyperplasia 7 74.16 Quite High
Endometrial Cancer 67 69.04 Quite High
Clear Cell Adenocarcinoma 1 60.16 Quite High
Metastasis 1 49.16 Quite Low
Genomic Instability 5 42.48 Quite Low
Microsatellite Instability 15 35.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In response to DNA damage, nuclear P53 accumulates and causes cell cycle arrest by inhibiting Cyclin D1 phosphorylation of the Rb gene and thereby promotes apoptosis.
P53 Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of Rb associated with apoptosis
1) Confidence 0.29 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 0.96 Pain Relevance 0

General Comments

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