INT305346

Context Info Confidence 0.41 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.91 Pain Relevance 0

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Pten (Mus musculus)

Pain Link Frequency Relevance Heat palliative 1 5.00 addiction 1 5.00 Pain 1 5.00 isoflurane 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Cancer 61 99.28 Endometrial Cancer 67 90.92 Apoptosis 4 68.32 Uterine Cancer 2 61.96 Targeted Disruption 14 56.56 Adhesions 1 41.12 Dislocations 2 24.64 Body Weight 1 21.00 Syndrome 1 18.96 Adenocarcinoma 1 12.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since PI3K was not activated following resistance exercise, we next sought to determine whether this pathway was increased due to inactivation of the 3-phosphatase PTEN.

Spec (whether) Positive_regulation (increased) of Spec (whether) Negative_regulation (inactivation) of PTEN

1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.06 Pain Relevance 0

PTEN inactivation is induced by mutations that lead to a loss of expression and is induced to a lesser extent by a loss of heterozygosity.

Positive_regulation (induced) of Negative_regulation (inactivation) of PTEN

2) Confidence 0.39 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 0.85 Pain Relevance 0

General Comments

This test has worked.