INT305408

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (ST8SIA2) Golgi apparatus (ST8SIA2) plasma membrane (KCNMA1)
carbohydrate metabolic process (ST8SIA2) transmembrane transport (KCNMA1)
KCNMA1 (Homo sapiens)
ST8SIA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 168 100.00 Very High Very High Very High
addiction 8 84.36 Quite High
local anesthetic 2 59.84 Quite High
Nav1.1 10 5.00 Very Low Very Low Very Low
Nav1.2 6 5.00 Very Low Very Low Very Low
Nav1.6 2 5.00 Very Low Very Low Very Low
conotoxin 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paralysis 2 92.52 High High
Fatigue 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since TTX and STX bind selectively with one toxin per channel, tritiated toxin has been successfully used to determine the density of Na channels in the membrane [27].
channel Binding (bind) of STX associated with tetrodotoxin
1) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0.09 Pain Relevance 0.38
In addition there is an unconfirmed report that one isoform group of the T type Ca channel (Cav3) binds TTX and STX and is blocked with low toxin affinity [17].

2.

channel Binding (binds) of STX associated with tetrodotoxin
2) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.86

General Comments

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