INT305483

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0.82

nucleus (MNX1)

MNX1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 41 99.64 Osteoarthritis 33 95.80 Pain 34 62.92 Inflammation 1 5.00 Mono iodoacetate 1 5.00 Arthritis 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 33 95.80 Injury 1 78.44 Pain 33 62.92 Osteophyte 7 5.00 Disease 3 5.00 Synovitis 2 5.00 Arthritis 1 5.00 Arrhythmias 2 Under Development 1 5.00 INFLAMMATION 1 5.00 Peripheral Arterial Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Reduction of osteochondral vascular density in MNX rats by MMP inhibitor treatment suggests that MMPs are also necessary for osteochondral angiogenesis in OA.

Negative_regulation (Reduction) of MNX associated with metalloproteinase and osteoarthritis

1) Confidence 0.04 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2853084 Disease Relevance 0.73 Pain Relevance 0.82

General Comments

This test has worked.