INT305526

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.70
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 21 96.52 Very High Very High Very High
Eae 15 96.32 Very High Very High Very High
Neuropathic pain 54 95.84 Very High Very High Very High
Peripheral nerve injury 3 85.28 High High
Sciatic nerve 12 79.04 Quite High
allodynia 3 76.40 Quite High
nociceptor 6 68.32 Quite High
Spinal cord 9 66.40 Quite High
Peripheral nervous system 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Megacolon 18 98.00 Very High Very High Very High
Injury 36 96.32 Very High Very High Very High
Neuropathic Pain 57 95.84 Very High Very High Very High
Nervous System Injury 6 94.84 High High
Hypersensitivity 15 92.04 High High
Targeted Disruption 39 83.04 Quite High
Congenital Anomalies 3 58.16 Quite High
Nociception 6 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since our findings in the in vitro experiments indicate that Runx1a has effects of its own, postnatal activation of Runx1a may not act as just a functional inhibitor of Runx1 long isoform activity.
Negative_regulation (inhibitor) of Positive_regulation (activation) of Runx1a
1) Confidence 0.42 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.91 Pain Relevance 0.64
This observation suggests that activation of Runx1a with DOX inhibits the activity of Runx1 long isoform activity, which, in turn, attenuates the development of CCI-induced neuropathic pain behavior.
Negative_regulation (inhibits) of Positive_regulation (activation) of Runx1a associated with eae and neuropathic pain
2) Confidence 0.42 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 1.43 Pain Relevance 0.90
The size of the litters was reduced in DOX-activated Sox10-rtTA/TRE-Runx1a animals.
Negative_regulation (reduced) of Positive_regulation (activated) of Runx1a
3) Confidence 0.42 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.36 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox