INT3056

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Context Info
Confidence 0.40
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 3.41
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgfr) plasma membrane (Ptgfr) signal transducer activity (Ptgfr)
Anatomy Link Frequency
uterine 6
livers 2
PGE2 2
Ptgfr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 212 100.00 Very High Very High Very High
Dismenorea 12 99.88 Very High Very High Very High
lidocaine 20 99.14 Very High Very High Very High
Kinase C 16 94.20 High High
aspirin 10 92.88 High High
Inflammation 31 91.48 High High
fibrosis 36 82.28 Quite High
adenocard 6 75.04 Quite High
anesthesia 2 58.68 Quite High
agonist 30 52.56 Quite High
Disease Link Frequency Relevance Heat
Fetal Death 2 100.00 Very High Very High Very High
Missed Abortion 1 100.00 Very High Very High Very High
Cancer 29 99.98 Very High Very High Very High
Dysmenorrhea 3 99.88 Very High Very High Very High
Adenocarcinoma 36 99.36 Very High Very High Very High
Reprotox - General 1 16 97.04 Very High Very High Very High
Endometriosis (extended) 38 96.36 Very High Very High Very High
Injury 8 95.84 Very High Very High Very High
INFLAMMATION 24 91.48 High High
Incomplete Abortion 1 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, cervical ripening induced by PGE2 does not depend on uterine contractions, and increased production of PGF2 alpha is unrelated to the ripening process.
Positive_regulation (increased) of Gene_expression (production) of PGF2 in PGE2 associated with dismenorea
1) Confidence 0.40 Published 1985 Journal Obstet Gynecol Section Abstract Doc Link 2857479 Disease Relevance 0.25 Pain Relevance 0.16
CONCLUSIONS: Ketorolac completely blocks ritodrine-stimulated production of PGF2 alpha in pregnant uterine tissues.
Positive_regulation (ritodrine-stimulated) of Gene_expression (production) of PGF2 in uterine
2) Confidence 0.29 Published 1993 Journal Obstet Gynecol Section Body Doc Link 8437778 Disease Relevance 0 Pain Relevance 0
PGF potentiates Butaprost-stimulated cAMP production via FP receptor-G?
Positive_regulation (stimulated) of Gene_expression (production) of FP receptor
3) Confidence 0.06 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
These results suggest that ritodrine stimulates PGF2 alpha production, and this may contribute to the tachyphylaxis that occurs with ritodrine and limits its long-term effectiveness as a tocolytic agent.
Positive_regulation (stimulates) of Gene_expression (production) of PGF2
4) Confidence 0.06 Published 1991 Journal Obstet Gynecol Section Abstract Doc Link 1923191 Disease Relevance 0 Pain Relevance 0.06
Finally, expression of the FP receptor also rapidly increases at the cell surface following H2O2 exposure, most likely by a similar mechanism to TP, but that this does not extend to EP3 and EP4.
Positive_regulation (increases) of Gene_expression (expression) of FP receptor
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.14 Pain Relevance 0.03
We have previously reported elevated FP receptor expression in endometrial adenocarcinomas (Sales et al., 2004b) and constructed and characterized an endometrial adenocarcinoma (Ishikawa) cell line expressing FP receptor (FPS cells) to the levels observed in endometrial adenocarcinomas (Sales et al., 2005).
Positive_regulation (elevated) of Gene_expression (expression) of FP receptor associated with adenocarcinoma and endometriosis (extended)
6) Confidence 0.05 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.29 Pain Relevance 0.07
[Induction of labor in missed abortion, fetal death and vesicular mole, using PGF2 alpha by extra-amniotic intracavitary administration].
Positive_regulation ([Induction) of Gene_expression (using) of PGF2 associated with missed abortion and fetal death
7) Confidence 0.05 Published 1977 Journal Minerva Ginecol Section Title Doc Link 609402 Disease Relevance 0.79 Pain Relevance 0.07
Our data highlight that in tumours expressing elevated levels of FP receptor, elevated biosynthesis of other prostanoids such as PGE2 can in the absence of the native ligand PGF2?
Positive_regulation (elevated) of Gene_expression (expressing) of FP receptor associated with cancer
8) Confidence 0.04 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.24 Pain Relevance 0.03
As shown for the specific FP receptor antagonist (AL8810), the PLC inhibitor (U73122) also abolished the InsP produced in response to treatment of FPS cells with 100nM PGE2 or 100nM PGF2?
Positive_regulation (shown) of Gene_expression (antagonist) of FP receptor associated with antagonist
9) Confidence 0.04 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.26
We have recently reported elevated expression of FP receptor in endometrial adenocarcinomas (Sales et al., 2004b, 2005).
Positive_regulation (elevated) of Gene_expression (expression) of FP receptor associated with adenocarcinoma
10) Confidence 0.04 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.65 Pain Relevance 0.05
These findings add additional support to the hypothesis that increased production of PGF2 alpha could contribute to the increased uterine contractility in primary dysmenorrhoea.
Positive_regulation (increased) of Gene_expression (production) of PGF2 in uterine associated with dismenorea
11) Confidence 0.03 Published 1983 Journal Prostaglandins Section Abstract Doc Link 6577521 Disease Relevance 0.25 Pain Relevance 0.25
These findings add additional support to the hypothesis that increased production of PGF2 alpha could contribute to the increased uterine contractility in primary dysmenorrhoea.
Positive_regulation (increased) of Gene_expression (production) of PGF2 in uterine associated with dismenorea
12) Confidence 0.02 Published 1983 Journal Prostaglandins Section Abstract Doc Link 6577521 Disease Relevance 0.25 Pain Relevance 0.25
In the present study we only investigated PGE2 levels since other studies have shown an increased production of various PGs including PGF1, PGF2?
Positive_regulation (increased) of Gene_expression (production) of PGF1
13) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.08 Pain Relevance 0.18
In livers receiving lidocaine alone, there was a slight but significant increase in the rate of 6-keto PGF1 alpha synthesis.
Positive_regulation (increase) of Gene_expression (synthesis) of PGF1 in livers associated with lidocaine
14) Confidence 0.01 Published 1983 Journal Adv Shock Res Section Abstract Doc Link 6349294 Disease Relevance 0.23 Pain Relevance 0.80
In contrast, DNP significantly stimulated 6-keto PGF1 alpha production from a control period value of 177 +/- 40 to 2,938 +/- 979 picograms/min/g wet weight after 180 minutes of perfusion.
Positive_regulation (stimulated) of Gene_expression (production) of PGF1
15) Confidence 0.01 Published 1983 Journal Adv Shock Res Section Abstract Doc Link 6349294 Disease Relevance 0.23 Pain Relevance 0.78

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