INT305741

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 1.01
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnk2, Sort1) cell differentiation (Sort1) endosome (Sort1)
Golgi apparatus (Sort1) endoplasmic reticulum (Sort1) enzyme binding (Sort1)
Anatomy Link Frequency
neurons 3
Kcnk2 (Mus musculus)
Sort1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 330 92.80 High High
depression 170 88.64 High High
antagonist 20 84.60 Quite High
potassium channel 30 81.48 Quite High
Pyramidal cell 20 73.92 Quite High
Raphe 20 62.00 Quite High
sSRI 45 26.96 Quite Low
fluoxetine 80 25.00 Low Low
Onset of action 15 25.00 Low Low
Nucleus accumbens 10 14.04 Low Low
Disease Link Frequency Relevance Heat
Depression 170 88.64 High High
Injury 10 56.08 Quite High
Stress 35 44.12 Quite Low
Neurodegenerative Disease 80 34.72 Quite Low
Anxiety Disorder 65 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Shock 15 5.00 Very Low Very Low Very Low
Body Weight 10 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Decapitation 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NTSR3/Sortilin interacted with the TREK-1 channel, as shown by immunoprecipitation of TREK-1 and NTSR3/Sortilin from COS-7 cells and cortical neurons co-expressing both proteins.
TREK-1 Binding (interacted) of NTSR3 in neurons
1) Confidence 0.54 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2854129 Disease Relevance 0.25 Pain Relevance 0.54
NTSR3/Sortilin interacted with the TREK-1 channel, as shown by immunoprecipitation of TREK-1 and NTSR3/Sortilin from COS-7 cells and cortical neurons co-expressing both proteins.
TREK-1 Binding (interacted) of Sortilin in neurons
2) Confidence 0.49 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2854129 Disease Relevance 0.25 Pain Relevance 0.54
This interaction between TREK-1 and NTSR3/Sortilin led us to examine whether NT and/or the partial NTSR3/Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity.
TREK-1 Binding (interaction) of NTSR3
3) Confidence 0.40 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.11 Pain Relevance 0.08
This interaction between TREK-1 and NTSR3/Sortilin led us to examine whether NT and/or the partial NTSR3/Sortilin propeptide (i.e. spadin) were able to act on TREK-1 channel activity.
TREK-1 Binding (interaction) of Sortilin
4) Confidence 0.36 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.11 Pain Relevance 0.08
NTSR3/Sortilin interacted with the TREK-1 channel, as shown by immunoprecipitation of TREK-1 and NTSR3/Sortilin from COS-7 cells and cortical neurons co-expressing both proteins.
TREK-1 Binding (immunoprecipitation) of Sortilin in neurons
5) Confidence 0.36 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2854129 Disease Relevance 0.30 Pain Relevance 0.56

General Comments

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